The thoroughly updated Fifth Edition of this landmark work has been completely overhauled to better represent the rapidly changing field of radiation oncology. This edition has an updated interior design including full-color throughout, and a new companion Website featuring the fully searchable text with all the images.

This comprehensive textbook provides an understanding of every aspect of radiation oncology—the natural history of cancer, the physical methods of radiation application, the effects of irradiation on normal tissues, and site-specific applications of radiation therapy either as a single modality or as part of a multimodality treatment program. This edition places greater emphasis on use of radiation oncology in palliative and supportive care as well as therapy. Six new chapters cover stereotactic irradiation outside the CNS; photodynamic therapy; radiation and gene therapy; prostate—intermediate and high risk; oncologic imaging/oncologic anatomy; and economics of radiation oncology. Other highlights include expanded coverage of new molecular biology and targeted therapies and greater emphasis on dose conformality, IMRT, IGRT, new radiation therapy delivery machines, radiosurgery, dose painting, and innovative brachytherapy.

Section I Overview and Basic Science of Radiation Oncology
• Chapter 1 The Discipline of Radiation Oncology
PART A: CANCER BIOLOGY
• Chapter 2 Biologic Basis of Radiation Therapy
PART B: MEDICAL RADIATION PHYSICS
• Chapter 5 Principles of Radiologic Physics, Dosimetry, and Treatment Planning
Section II Techniques, Modalities, and Modifiers in Radiation Oncology
• Chapter 11 Altered Fractionation Schedules
• Chapter 12 Late Effects of Cancer Treatment on Normal Tissues
• Chapter 13 Methodology of Clinical Trials
• Chapter 14 Total-Body and Hemibody Irradiation
• Chapter 15 Stereotactic Radiosurgery and Radiotherapy
• Chapter 19 Physics and Biology of Brachytherapy
• Chapter 20 Clinical Applications of Brachytherapy: Low-Dose-Rate and Pulse-Dose-Rate
• Chapter 22 Clinical Aspects and Applications of High-Dose-Rate Brachytherapy
• Chapter 23 Radioimmunoglobulins and Nonsealed Radionuclide Therapy
• Chapter 24 Photodynamic Therapy
• Chapter 28 Hyperthermia
• Chapter 29 Basic Concepts of Chemotherapy and Irradiation Interaction
Section III Clinical Radiation Oncology
• PART A: SKIN CANCER
• Chapter 30 Skin
• PART B: AIDS-RELATED MALIGNANCIES
• Chapter 31 Malignant Neoplasms Associated with the Acquired Immunodeficiency Syndrome
• PART C: CENTRAL NERVOUS SYSTEM TUMORS
• Chapter 32 Primary Intracranial Neoplasms
• Chapter 33 Pituitary
• Chapter 34 Spinal Canal
PART D: HEAD AND NECK TUMORS
• Chapter 35 Eye and Orbit
• Chapter 36 Ear
• Chapter 40 Salivary Glands
• Chapter 41 Oral Cavity Cancer
PART E: THORACIC TUMORS
• Chapter 48 Lung
• Chapter 49 Mediastinum and Trachea
• Chapter 50 Esophageal Cancer
• Chapter 51 Tumors of the Heart and Great Vessels
PART F: BREAST TUMORS
• Chapter 52 Breast: Stage Tis
• Chapter 53 Early Stage Breast Cancer
<PART G: GASTROINTESTINAL TUMORS
• Chapter 55 Stomach
• Chapter 56 Cancer of the Pancreas
• Chapter 57 Liver and Hepatobiliary Tract
PART H: URINARY TRACT TUMORS
• Chapter 60 Kidney, Renal Pelvis, and Ureter
• Chapter 61 Bladder
PART I: MALE GENITOURINARY TUMORS
• Chapter 62 Low-Risk Prostate Cancer
• Chapter 63 Intermediate-and High-Risk Prostate Cancer
PART J: GYNECOLOGIC TUMORS
• Chapter 66 Uterine Cervix
• Chapter 67 Endometrium
• Chapter 68 Ovary
PART K: ADRENAL AND RETROPERITONEAL TUMORS
• Chapter 73 Retroperitoneum
• Chapter 74 Adrenal Gland
PART L:LYMPHOMA AND HEMATOLOGIC TUMORS
• Chapter 75 Hodgkin Lymphoma
• Chapter 77 Cutaneous T-Cell Lymphoma
• Chapter 78 Leukemia
PART M: SARCOMAS OF BONE AND SOFT TISSUE
• Chapter 80 Osteosarcoma
• Chapter 81 Soft Tissue Sarcomas (Excluding Retroperitoneum)
PART N: PEDIATRIC TUMORS 1822 Chapter 82 Central Nervous System Tumors in Children
• Chapter 83 Wilms' Tumor
• Chapter 84 Neuroblastoma
• Chapter 88 Unusual Tumors in Childhood
PART O: BENIGN DISEASES
• Chapter 89 Radiotherapy of Non-Malignant Diseases
• Chapter 90 Endovascular Brachytherapy
• Chapter 92 Palliation of Bone Metastases
• Chapter 95 Supportive Care and Quality of Life
Section V Economics, Ethics, and Technology Assessment
• Chapter 96 Technology Assessment, Cost Benefit, Outcome Analysis Research and Evidence-Based Radiation Oncology
• Chapter 97 Ethics, Professional Values, and Legal Considerations in Radiation Oncology
• Chapter 98 The Economics of Radiation Oncology
INDEX