(To see other currencies, click on price)
MORE ABOUT THIS BOOK
Main description:
A workshop on "MOLECULAR ASPECTS OF MYELOID STEM CELL DEVELOPMENT" was held at the Historic Inns in Annapolis, MD during April 30-May 3, with approximately 70 persons attend ing. The enormous success of this meeting was attributable to the recent outburst of information generated from two areas of study: transcriptional regulation of developmentally important myeloid genes and molecular dissection of chromosomal abnormalities in human myeloid leukemias. It was reassuring that studies of normal myelopoiesis and abnormal myelopoiesis, as observed in dys plasias and neoplasia, are revealing several interrelated mechan isms of gene regulation. However, great challenges await us as we try to determine how these and other mechanisms in this intricate system orchestrate the ultimate fate of cells e. g. proliferation, differentiation or apoptosis. This volume of Current Topics in Micro biology encapsulates many of the key aspects of the workshop summarizing research over the past few years on the ontogeny and pathology of myeloid cells. Investigations into the complex process of normal myeloid cell . maturation were first made possible through development of in vitro clonigenic assays. These established the relationships of colony stimulating factors, interleukins and their combinations to the specific fates of myeloid progenitors derived from the bone , marrow and spleen. Molecular studies became feasible, however, through the later establishment of several cell culture systems in volving immortalized cells which, under the proper induction, could fairly accurately recapitulate the myelopoietic process.
Contents:
Regulation of Myeloid Differentiation, Growth Arrest and Apoptosis.- Molecular Control of Development in Normal and Leukemic Myeloid Cells by Cytokines, Tumor Suppressor and Oncogenes.- Retinoic Acid Receptors in Hematopoiesis.- Role of c-myc in Myeloid Differentiation, Growth Arrest and Apoptosis.- Self Renewal and Differentiation in Primary Avian Hematopoietic Cells: An Alternative to Mammalian in Vitro Models?.- Receptors and Signal Transduction.- The Effect of C-raf Antisense Oligonucleotides on Growth Factor-Induced Proliferation of Hematopoietic Cells.- Protein Kinase C-?, an Important Signaling Molecule in the Platelet-Derived Growth Factor ? Receptor Pathway.- Novel Adapter Proteins that Link the Human GM-CSF Receptor to the Phosphatidylinositol 3-Kinase and Shc/Grb2/ras Signaling Pathways.- Myb: Proliferation and Maintenance of Stage Specific Genes.- Functional Analysis of the c-myb Proto-Oncogene.- Structure and Function of the Proteins Encoded by the myb Gene Family.- The c-Myb Negative Regulatory Domain.- Myeloid-Specific Transcription.- Terminal Myeloid Gene Expression and Differentiation Requires the Transcription Factor PU.1.- A Role for STAT Family Transcription Factors in Myeloid Differentiation.- Regulation of C/EBP?/NF-M Activity by Kinase Oncogenes.- Function of PU.1 (Spi-1), C/EBP, and AML1 in Early Myelopoiesis: Regulation of Multiple Myeloid CFS Receptor Promoters.- Regulation of Immature Myeloid Cell Differentiation by PEBP2/CBF, MYB, C/EBP and ETS Family Members.- Hematopoietic Transcriptional Regulation by the Myeloid Zinc Finger Gene, MZF-1.- Coordinate Regulation of Neutrophil Secondary Granule Protein Gene Expression.- lnterleukin-5 Receptor ? Subunit Gene Regulation in Human Eosinophil Development: Identification of a Unique Cis-Element that acts lie an Enhacer in Regulating Activity of the IL-5R? Promoter.- Molecular Aspects of Myeloid Leukemia. I. Murine Studies.- Retroviral Insertional Mutagenesis in Murine Promonocytic Leukemias:c-myband Mm/1..- Molecular Analysis and Characterization of Two Myeloid Leukemia Inducing Murine Retroviruses.- Molecular Analysis of Evil, a Zinc Finger Oncogene Involved in Myeloid Leukemia.- Activation of Stat-related DNA-binding Factors by Erythropoietin and the Spleen Focus-Forming Virus.- The Neurofibromatosis Type 1 (NF1) Tumor Suppressor Gene and Myeloid Leukemia.- Molecular Aspects of Myeloid Leukemia. II. Human Studies.- Rearrangement of the AML1/CBFA2 Gene in Myeloid Leukemia with the 3;21 Translocation:Expression of Co-Existing Multiple Chimeric Genes with Similar Functions as Transcriptional Repressors, but with Opposite Tumorigenic Properties.- Transcriptional Regulation by the t(8;21 )Fusion Protein, AML-1/ETO.- The Mixed Lineage Leukemia (MLL) Protein Involved in 11 q23 Translocations Contains a Domain that Binds Cruciform DNA and Scaffold Attachment Region (SAR) DNA.- Pathogenetic Role of the PML/RAR? Fusion Protein in Acute Promyelocytic Leukemia.- Involvement of the TEL Gene in Hematologic Malignancy by Diverse Molecular Genetic Mechanisms.- Transforming Properties of the Leukemic Inv(16) Fusion Gene CBFB-MYH11..
PRODUCT DETAILS
Publisher: Springer (Springer-Verlag Berlin and Heidelberg GmbH & Co. K)
Publication date: December, 2011
Pages: 312
Weight: 487g
Availability: Available
Subcategories: Immunology
From the same series
Eric Vivier
Kevin V. Morris
Esteban Domingo
Eric Vivier
Tomohiro Kurosaki
Christian Munz
Christian Munz
Michael G. Katze
Bryan R. Cullen
David S. Goodsell
G. Singh Chhatwal
Ralf Bartenschlager
Ellen Heber-Katz
Andreas Rummel
Juan J. Lafaille
Thomas E. Shenk
Ben Adler
Michael B. A. Oldstone
Friedrich Koch-Nolte
Marco Falasca
Michael B. A. Oldstone
Benhur Lee
Freddy Radtke
Klaus Aktories
Jean Langhorne
Michael B. A. Oldstone
Jeremy Nuttall
Robert N. Eisenman
Z F Fu
Peter K. Vogt
Tatsuji Nomura
Wilfried Ellmeier
Marc Daeron
H. Koprowski
Hilary Koprowski
Simon Fillatreau
G. Balakrish Nair
Harris G. Fienberg
Michael B. A. Oldstone
R.M.E. Parkhouse
Lars B. Olding
Charles L. Sawyers
Cornelis Murre
Nicholas Mantis
Pamela A. Kozlowski
Charles E. Samuel
Larry J. Anderson
Kenneth Palmer
Marcel B.M. Teunissen
Rudolf Valenta
M.B.A. Oldstone
Thomas Boehm
Cesare Montecucco
Michael B.A. Oldstone
Hubert Hilbi
Hilary Koprowski
Hung Y. Fan
Walter Doerfler
Polly Roy
Michael Karin
Bryan R. Cullen
Glenn Dranoff
Rafi Ahmed
Jurgen A.. Richt
Ulrich Dobrindt
Ellen Heber-Katz
G. Singh Chhatwal
Ralf Bartenschlager
Peter K. Vogt
Robert L. Coffman
Michael G. Katze
Harald Stenmark
Andreas Rummel
Christian Rommel
Fritz Melchers
H. Koprowski
Didier Trono
Uwe Gross
Christian Rommel
M. Celeste Simon
John E. Johnson
K. Takada
Ellen Heber-Katz
C. Schmaljohn
Axel Rethwilm
Jerry L. Workman
Louis B. Justement
Marco Falasca
P.K. Vogt
Michael N. Hall
M.B.A. Oldstone
K. Hirai
Eric Vivier
Allison Abendroth
Oystein Bruserud
Carolyn Wilson
Freddy Radtke
Benhur Lee
Klaus Aktories
Harald Zur Hausen
J.S. Mackenzie
Adrienne E. Clarke
Stefan H.E. Kaufmann
Bernhard Fleischer
Michael Potter
H. Koprowski
H. Koprowski
Rolf Jessberger
Charles L. Sawyers
Chihiro Sasakawa
Vojo Deretic
Alan L. Rothman
Marco Colonna
H. Koprowski
Karl Maramorosch
H. Koprowski
Eckhard R. Podack
Paul Spearman
Takashi Saito
H. Koprowski
W. Doerfler
Michael Loos
H. Koprowski
Daniel Kolakofsky
H. Koprowski
H. Koprowski
Michael Potter
Kenneth I. Berns
H. Koprowski
J. Lindsay Whitton
Fritz Melchers
Nicholas Mantis
Cornelis Murre
Pamela Kozlowski
Klaus Aktories
Fritz Melchers
O. Haller
Peter K. Vogt
Norman L. Letvin
Dan R. Littman
Michael Potter
Robert F. Ramig
Gillian M. Griffiths
H. Koprowski
David Gray
T.A. Trautner
Michael B. A. Oldstone
Jiri Mestecky
Richard W. Moyer
Fritz Melchers
Michael B. A. Oldstone
Guido Kroemer
Hilary Koprowski
H. Koprowski
Peter K. Vogt
Bruce W. Chesebro
Charles J. Parker
P.J. Sansonetti
H. Koprowski
Rolf Knippers
Walter Doerfler
Klaus Jann
Virginia L. Miller
Marie H. Kosco-Vilbois
Peggy J. Farnham
Peter M Schlag
Thomas M. Shinnick
Hilary Koprowski
Anthony J. Pawson
Walter Doerfler
Peter K. Vogt
Klaus Jann
Vincent R. Racaniello
Nicholas Muzyczka
Mark Bothwell
Volker Ter Meulen
Jean-Pierre Kraehenbuhl
Michael B. A. Oldstone
P.H. Hofschneider
Steinunn Baekkeskov
H. Koprowski
F. Melchers
Garnett Kelsoe
Arthur E. Frankel
Michael B. A. Oldstone
Michael B. A. Oldstone
Peter Sarnow
Hermann Wagner
Rudolf Rott
H.L. Robinson
Fritz Melchers
John J. Holland
Jeffrey L. Dangl
Richard W. Compans
Charles Mackay
Beat A. Imhof
H. Koprowski
P.K. Vogt
H. Koprowski
P.A. Bachmann
P.K. Vogt
W. Doerfler
H. Koprowski
P.K. Vogt
Leslie Hudson
Michael Potter
Fritz Melchers
Michael B. A. Oldstone
William S. Mason
Peter K. Vogt
H. Koprowski
P.K. Vogt
Melvin J. Bosma
James K. McDougall
Stefan H.E. Kaufmann
N.J. Dimmock
Peter K. Vogt
Michael B. A. Oldstone
Walter Orenstein
Hans-Georg Krausslich
Fritz Melchers
Christa E. Muller-Sieburg
John D. Lambris
Siamon Gordon
Hermann Wagner
H. Koprowski
Hilary Koprowski
D.B. Willis
Walter Doerfler
A. J. Shatkin
P.K. Vogt
Christopher J. Paige
Michael Potter
Michael B. A. Oldstone
W. Doerfler
Henry C. Wu
Hermann Wagner
Michael B. A. Oldstone
H. Koprowski
H. Koprowski
H. Koprowski
H. Koprowski
Barry T. Rouse
H. Koprowski
Fritz Melchers
H. Koprowski
H. Koprowski
H. Koprowski
H. Koprowski
Charles E. Samuel
F. Melchers
H. Koprowski
H. Koprowski
H. Koprowski
Hans-Dieter Klenk
David W. Weiss
U.H. Koszinowski
Ernst-L. Winnacker
Steven Tracy
L. Du Pasquier
Michael B. Kastan
H. Wagner
Fritz Melchers
Ursula Gunthert
T. Ulf Westblom
P.K. Vogt
Lena Claesson-Welsh
C.H. Hagedorn
Stanley B. Prusiner
Wolfgang Baumeister
Bruce Beutler
Louis B. Justement
Ursula Gunthert
Marcel B.M. Teunissen
Rudolf Valenta
Michael Karin
Glenn Dranoff
Rafi Ahmed
Inger Helene Madshus
Lyubomir T. Vassilev
Martin L. Privalsky
Walter Doerfler
Alexander Steinkasserer
Dennis R. Burton
T.M. Koehler
Jurgen A.. Richt
Walter Doerfler
David A. Harris
Yoshihiro Kawaoka
Paula M. Pitha
Branch D. Moody
Scott Dessain
James L. van Etten
Michael B. A. Oldstone
Tony Romeo
Rafi Ahmed
Steven Tracy
Harald Zur Hausen
Michael B. A. Oldstone
Thomas E. Lane
Tasuku Honjo
Marianne Manchester
Walter Doerfler
Diane E. Griffin
Mark Marsh
Alexander V. Karasev
Dorian McGavern
B. W. J. Mahy
Riccardo Dalla-Favera
Sanjeev Krishna
Patrice Boquet
Klaus Aktories
Luis Enjuanes
Christian Rommel
Christian Rommel
M. Celeste Simon
John E. Johnson
Oystein Bruserud
Allison Abendroth
Peter E. Lipsky
Walter Doerfler
Stanley A. Plotkin
John L. Casey
William M. Shafer
Esteban Domingo
Eric Vivier
Takashi Saito
Paul Spearman
Chihiro Sasakawa
Alan L. Rothman
Vojo Deretic
Walter Orenstein
Dorian McGavern
Alexander V. Karasev
Harald Zur Hausen
Michael B. A. Oldstone
Michael B. A. Oldstone
James L. van Etten
Marianne Manchester
Thomas E. Shenk
Tatsuji Nomura
Tony Romeo
Steven Tracy
Peter K. Vogt
Scott Dessain
Paula M. Pitha
D.B. Moody
Peter K. Vogt
Robert A. Weiss
Rafi Ahmed
Stanley A. Plotkin
Tasuku Honjo
Walter Doerfler
William M. Shafer
John L. Casey
Peter E. Lipsky
Thomas E. Lane
Robert N. Eisenman