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Immunology and Immunopathogenesis of Malaria
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Main description:

Malaria is still a major global health problem, killing more than 1 million people every year. Almost all of these deaths are caused by Plasmodium falciparum, one of the four species of malaria parasites infecting humans. This high burden of mortality falls heavily on Sub-Saharan Africa, where over 90% of these deaths are thought to occur, and 5% of children die before the age of 5 years. The death toll from malaria is still growing, with malaria-specific mortality in young African children estimated to have doubled during the last twenty years. This increase has been associated with drug resistance of the parasite, spread of insecticide resistant mosquitoes, poverty, social and political upheaval, and lack of effective vaccines.


This collection of reviews addresses many of these important issues of malarial immunity and immunopathology. They are of interest not only to malariologists, but hopefully also to the broader immunological community. Strong interactions with, and feedback from immunologists working in other infectious diseases and in basic immunology will help us to move the field of malaria immunology and therapeutic intervention forward more quickly.


Feature:

Addresses vital questions of immunopathology surrounding malaria, which kills more than 1 million people annually



Discusses drug resistance of the parasite, insecticide resistance of the mosquito, and the effects of poverty and social and political upheaval



Includes useful insight and feedback from immunologists working in other infectious diseases



Will be of interest to malariologists, and also to the broader immunological community


Back cover:

Malaria is still a major global health problem, killing more than 1 million people every year. Almost all of these deaths are caused by Plasmodium falciparum, one of the four species of malaria parasites infecting humans. This high burden of mortality falls heavily on Sub-Saharan Africa, where over 90% of these deaths are thought to occur, and 5% of children die before the age of 5 years. The death toll from malaria is still growing, with malaria-specific mortality in young African children estimated to have doubled during the last twenty years. This increase has been associated with drug resistance of the parasite, spread of insecticide resistant mosquitoes, poverty, social and political upheaval, and lack of effective vaccines.


This collection of reviews addresses many of these important issues of malarial immunity and immunopathology. They are of interest not only to malariologists, but hopefully also to the broader immunological community. Strong interactions with, and feedback from immunologists working in other infectious diseases and in basic immunology will help us to move the field of malaria immunology and therapeutic intervention forward more quickly.


Contents:

Preface.- The dissection of CD8 T cells during liver-stage infection.- Early interactions between blood-stage plasmodium parasites and the immune system.- Longevity of the immune response and memory to blood-stage malaria.- Experimental models of cerebral malaria.- Glycosylphosphaditidylinositols in malaria pathogenesis and immunity; potential for therapeutic intervention.- The immunology and pathogenesis of malaria during pregnancy.- Subject index


PRODUCT DETAILS

ISBN-13: 9783642421846
Publisher: Springer (Springer Berlin Heidelberg)
Publication date: September, 2014
Pages: 248
Weight: 385g
Availability: POD
Subcategories: Immunology
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