With the prevalence of neurodegenerative diseases on the rise as average life expectancy increases, the hunt for effective treatments and preventive measures for these disorders is a pressing challenge. Neurodegenerative disorders such as Alzheimer’s disease, Huntington’s disease, Parkinson’s disease and amyotrophic lateral sclerosis have been termed ‘protein misfolding disorders’ that are char- terized by the neural accumulation of protein aggregates. Manipulation of the cellular stress response involving the induction of heat shock proteins offers a the- peutic strategy to counter conformational changes in neural proteins that trigger pathogenic cascades resulting in neurodegenerative diseases. Heat shock proteins are protein repair agents that provide a line of defense against misfolded, aggregati- prone proteins. Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection reviews current progress on neural heat shock proteins (HSP) in relation to neurodegenerative diseases (Part I), neuroprotection (Part II), ext- cellular HSP (Part III) and aging and control of life span (Part IV). Key basic and clinical research laboratories from major universities and hospitals around the world contribute chapters that review present research activity and importantly project the field into the future. The book is a must read for researchers, postdoctoral fellows and graduate students in the fields of Neuroscience, Neurodegenerative Diseases, Molecular Medicine, Aging, Physiology, Pharmacology and Pathology.
Written by leaders in the field of neurodegenerative diseases and neuroprotection
Provides up-to-date reviews on the most recent concepts of the role of heat shock proteins in repair and protective mechanisms in the brain
Contains chapters with in-depth reviews on i) heat shock proteins and neurodegenerative diseases, ii) heat shock proteins and neuroprotection, iii) extracellular heat shock proteins and the nervous system and iv) aging, control of life span and expression of heat shock proteins
Part I: Heat Shock Proteins and Neurodegenerative Diseases: 1. Chaperones and Polyglutamine Expansion Disorders, Martin L. Duennwald; 2. Heat Shock Proteins, Unfolded Protein Response Chaperones and Alzheimer's Disease, Jordi Magrane and Henry W. Querfurth; 3. Cellular and Molecular Mechanisms Underlying Parkinson's Disease: The Role of Molecular Chaperones, Pamela J. McLean; 4. Heat Shock Proteins as Therapeutic Targets in Amyotrophic Lateral Sclerosis, Bernadett Kalmar and Linda Greensmith; 5. The Role of Chaperones and Co-Chaperones in Retinal Degenerative Diseases, Maria Kosmaoglou, Tatiana V. Novoselova and Michael E. Cheetham; 6. Neuroprotective Features of Hsp90 Inhibitors Exhibiting Anti-Inflammatory Actions: Implications for Multiple Sclerosis, Douglas L. Feinstein, Alessandra Spagnolo and Cinzia Dello-Russo; 7. Role of HspB1 and HspB8 in Hereditary Peripheral Neuropathies: Beyond the Chaperone Function, Serena Carra and Jacques Landry; Part II: Heat Shock Proteins and Neuroprotection: 8. Heat Shock Proteins Hsp70 and Hsp27 and Neural Cellular Protection, Tracy S. Voegeli, Amanda J. Wintink and R. William Currie; 9. Molecular Chaperones and Protection in Animal and Cellular Models of Ischemic Stroke, Yi-Bing Ouyang, Lijun Xu and Rona G. Giffard; 10. Strategies for Conferring Neuroprotection and Countering the High Threshold for Induction of the Stress Response in Motor Neurons, Heather D. Durham; 11. Use of Viral Gene Delivery Systems to Investigate Neuroprotective Roles of Hsp70 and Hsp40 Proteins, Joanna Howarth, Do-Young Lee and James B. Uney; 12. Heat Shock Proteins at the Synapse: Implications for Functional Protection of the Nervous System, Ian R. Brown; Part III: Extracellular Heat Shock Proteins and the Nervous System: 13. Release of Heat Shock Proteins and their Effects when in the Extracellular Space in the Nervous System, Michael Tytell, Mac B. Robinson and Carolanne E. Milligan; 14. Silencingof Metastasis-Associated Gene 1 (mta1) Stimulates Hsp70 Cellular Release and Neurite Extension in Neuroblastoma Cells, Preethi Rao and Alexzander Asea; 15. Extracellular Chaperones and Amyloids, Mark R. Wilson, Justin J. Yerbury and Stephen Poon; Part IV: Aging, Control of Life Span and Expression of Heat Shock Proteins: 16. Neural Expression of Small Heat Shock Proteins Influences Longevity and Resistance to Oxidative Stress, Robert M. Tanguay and Geneviève Morrow; 17. Mechanistic Links Between Aging and Aggregation-Mediated Proteotoxicity: Role of HSF-1 and DAF-16, Ehud Cohen and Andrew Dillin; 18. Protein Quality Control and Heat Shock Gene Expression in the Nervous System, Stuart K. Calderwood; 19. Serum HSP70 Level as a Biomarker of Exceptional Longevity, Dellara F. Terry and Alexzander Asea; Index