Main description:

The book Heat Shock Protein-Based Therapies provides the most up-to-date review on new heat shock protein-based mechanisms used in the therapy and treatment of various human disorders and diseases, including cancer, muscular atrophy, neurodegenerative disorders (Alzheimer's Disease, Multiple Sclerosis) and infectious diseases (HIV, periodontal disease). Written by leaders in the field of heat shock protein research, the chapters systematically and in a step wise fashion takes the reader through the fascinating sequence of events by which mechanisms dependent on heat shock proteins are targeted. The chapters also provide answers as to HSP biological significance to the host. This book is a must read for graduate and postgraduates in the field of Drug Development, Biotechnology, Pharmaceutical Industry, Phytomedicine, Biology (plant and mammal), Biochemistry (pro- and eukaryotic), Oncology, Immunology, Microbiology, Exercise Medicine, Physiology, Inflammatory diseases, Autoimmunity, Pharmacology and Pathology.

Contents:

Contents

Contributors
Preface

SECTION I: HEAT SHOCK PROTEIN HSP27-BASED THERAPIES
1 HSP27 as a Therapeutic Target of Novel Inhibitors and Dietary Phytochemicals in Cancer
Elena Arechaga-Ocampo and Cesar Lopez-Camarillo
2 Heat Shock Protein 27 (HSP27, HSPB1) is Up-Regulated by Targeted Agents and Confers Resistance to Both Targeted Drugs and Chemotherapeutics
Daniele Musiani, John D. Konda, Simona Pavan, Erica Torchiaro, Jessica Erriquez, Martina Olivero and Maria F. Di Renzo

3 Heat Shock Proteins and Cancer: Plant Based Therapy
Evren OEnay-Ucar

SECTION II: HEAT SHOCK PROTEIN HSP60-BASED THERAPIES
4 Chaperonotherapy for Alzheimer's Disease: Focusing on HSP60
Francesco Cappello, Antonella M. Gammazza, Silvia Vilasi, Maria G. Ortore, Pier L. San-Biagio, Claudia Campanella, Andrea Pace, Antonio P. Piccionello, Giulio Taglialatela, Everly C. De Macario and Alberto J. l. Macario

5 Secreted and Circulating Cell Stress Proteins in the Periodontal Diseases
Brian Henderson, Nikos Donos, Luigi Nibali and Frank Kaiser

SECTION III: HEAT SHOCK PROTEIN HSP70-BASED THERAPIES

6 The Role of Heat Shock Protein 70 in Infection and Immunity
Jose Rey-Ladino, Abiola Senok, Abdullah Sarkar and Ahlam Al Shedoukhy

7 Potential Cytoprotective Effects of Heat Shock Proteins to Skeletal Muscle
John P. Vardiman, Philip M. Gallagher and Jacob A. Siedlik

8 Heat Shock Proteins in Triple-Negative Breast Cancer (TNBC) TreatmentPunit Kaurunit Kaur, Tarundeep arundeep Singh, Moses Galukandealukande, Sunil Krishnanrishnan and Alexzander A. A. Asealexzander Asea

9 Heat Shock Proteins in Multiple Sclerosis Pathogenesis: Friend or Foe?
Rosaria Tinnirello, Giuseppina Turturici, Gabriella Sconzo, Walter Spinello, Alexzander A. A. Asea and Fabiana Geraci

10 New Indications for HSP90 and HSP70 Inhibitors as Antiviral Drugs
Matthew K. Howe and Timothy A. J. Haystead

11 Potential Applications of Nanoparticles for Hyperthermia
Caio C. Quini and Sunil Krishnan

SECTION IV: HEAT SHOCK PROTEIN HSP90-BASED THERAPIES

12 Gene Therapy Against HSP90: Glucocorticoid Receptor-Assisted Cancer Treatment
Susanta S. Adhikari, Sujan K. Mondal and Rajkumar Banerjee

13 Potential of HSP90 Inhibitors to Treat Neurofibromatosis-Related Tumors
Jeremie Vitte and Marco Giovannini

14 Role of Heat Shock Protein 90 in the Cause of Various Diseases: A Potential Therapeutic Target
Subhankar Paul

15 HSP90 Inhibitor-Based Strategies for Cancer Therapy: Advancing Toward Clinical Impact
David A. Proia and Richard C. Bates

16 Molecular Survival Strategies of Organisms: HSP and Small Molecules for Diagnostics and Drug Development
Andreas Kirschning, Johanna-Gabriela Walter, Frank Stahl, Emilia Schax, Thomas Scheper, Pooyan Aliuos and Carsten Zeilinger
17 Targeting Heat Shock Proteins in Colorectal Cancer
Sheah L. Lee, Nina C. Dempsey-Hibbert, Dale Vimalachandran, Terence D. Wardle, Paul Sutton and John H. H. Williams

Index