Main description:

Mitochondria produce the chemical energy necessary for eukaryotic cell functions; hence mitochondria are an essential component of health, playing roles in both disease and aging. More than 80 human diseases and syndromes are associated with mitochondrial dysfunction; this book focuses upon diseases linked to these ubiquitous organelles. Accumulation of mitochondrial DNA damage results in mitochondrial dysfunction through two main pathways. Mutation in mitochondrial DNA causes diseases such as Kearns-Sayre syndrome and Pearson syndrome. Mutation in chromosomal DNA causes diseases such as Parkinson's disease and schizophrenia. These and many other diseases are reviewed in this book.

Key Features

Presents the detailed structure of mitochondria, mitochondrial function, roles of oxidants and antioxidants in mitochondrial dysfunction.

Includes summary of both causes and effects of these diseases.

Discusses current and potential future therapies for mitochondrial dysfunction diseases

Explores a wide variety of diseases caused by dysfunctional mitochondria.

Contents:

Contents

Preface ........................................................................................................................................................................... xi

Acknowledgment......................................................................................................................................................... xiii

About the Editor .......................................................................................................................................................... xv

Contributors ............................................................................................................................................................... xvii

SECTION I Introduction: Structure and Function of Mitochondria

Chapter 1 Mitochondrial Structure and Function ....................................................................................................... 3

Marcos Roberto de Oliveira

Chapter 2 Structure, Function and Evolutionary Aspects of Mitochondria ................................................................ 9

Puja Agarwal, Mehali Mitra, and Sujit Roy

Chapter 3 Mitochondrial Genome Damage, Dysfunction and Repair ........................................................................23

Kalyan Mahapatra, Sayanti De, and Sujit Roy

SECTION II Mitochondrial Dysfunction and Diseases

Chapter 4 Instability of Human Mitochondrial DNA, Nuclear Genes and Diseases ..................................................39

Katarzyna Tonska

Chapter 5 Kearns-Sayre Syndrome .............................................................................................................................55

Josef Finsterer

Chapter 6 Mitochondrial Dysfunction and Barth Syndrome......................................................................................61

Arianna F. Anzmann, Steven M. Claypool, and Hilary Vernon

Chapter 7 Mitochondrial Dysfunction in the Pathophysiology of Alzheimer's Disease ..............................................79

Isaac G. Onyango

Chapter 8 Mitochondrial Dysfunction in Multiple Sclerosis.......................................................................................87

Angela Dziedzic, Elzbieta Miller, Joanna Saluk-Bijak, and Michal Bijak

Chapter 9 Mitochondrial Dysfunction in Chronic Kidney Disease.............................................................................93

Maria V. Irazabal and Alfonso Eirin

Chapter 10 Mitochondrial Dysfunction in Breast Cancer: A Potential Target from the Bench to Clinical

Therapeutics.............................................................................................................................................103

Thalita Basso Scandolara, Leticia Madureira Pacholak, Thayse Fachin Cormanique, Rodrigo Kern,

and Carolina Panis

Chapter 11 Mitochondrial Dysfunction and DNA Methylation in Atherosclerosis ....................................................115

Silvio Zaina and Gertrud Lund

Chapter 12 Mitochondrial Dysfunction and Heart Diseases ......................................................................................127

Dao-Fu Dai

Chapter 13 The Role of Mitochondrial Dysfunction in Mitophagy and Apoptosis and Its Relevance to Cancer .......143

Jan Jezek

Chapter 14 Mitochondrial Dysfunction Linking Obesity and Asthma .......................................................................151

Naveen K. Bhatraju and Anurag Agrawal

Chapter 15 Mitochondrial Dysfunction and Hearing Loss.........................................................................................163

Maria de la Luz Arenas Sordo

Chapter 16 Superoxide Dismutase, Mitochondrial Dysfunction, and Neurodegenerative Diseases ............................171

Jahaun Azadmanesh and Gloria E. O. Borgstahl

Chapter 17 Role of Post-Translational Modifications of Mitochondrial Complex I in Mitochondrial Dysfunction

and Human Brain Pathologies .................................................................................................................191

Vismaya, Yogachar Chithra, and Muchukunte Mukunda Srinivas Bharath

Chapter 18 Heme Oxygenase-1 in Kidney Health and Disease: Perspective of Mitochondrial Homeostasis ..............205

Pu Duann, Elias A. Lianos, and Pei-Hui Lin

Chapter 19 Mitochondrial Transplantation in Myocardial Ischemia and Reperfusion Injury ....................................217

David Blitzer, Borami Shin, Alvise Guariento, Pedro J. del Nido, and James D. McCully

Chapter 20 Mitochondrial Dysfunction in Diabetes ...................................................................................................231

Eric L. Johnson

Chapter 21 Clinical Manifestation of Mitochondrial Disorders in Childhood............................................................243

Martin Magner

Chapter 22 Mitochondrial Dysfunction and Epilepsies ..............................................................................................265

Bindu Parayil Sankaran and Arun B. Taly

Chapter 23 Mitochondrial Dysfunction and Allergic Disease.....................................................................................277

Kritika Khanna and Anurag Agrawal

SECTION III Factors Affecting Mitochondrial Function

Chapter 24 Role of Carnosic Acid in Protection of Brain Mitochondria ....................................................................293

Marcos Roberto de Oliveira

Chapter 25 Mitochondrial Dysfunction and Its Impact on Oxidative Capacity of Muscle .........................................309

Teet Seene

Chapter 26 The Effects of Resveratrol on the Brain Mitochondria.............................................................................319

Marcos Roberto de Oliveira

Chapter 27 Pathophysiology and Biomarkers of Mitochondrial Dysfunction Induced by Heavy Exercise .................335

Sergej M. Ostojic

Chapter 28 Mitochondrial Pathologies and Their Neuromuscular Manifestations .....................................................341

Carlos Ortez and Andres Nascimento

Chapter 29 Mitochondrial Stress and Cellular Senescence..........................................................................................361

Irene L. Tan and Michael C. Velarde

Chapter 30 Role of Mitochondrial Dysfunction in Human Obesity ...........................................................................379

David Albuquerque, Sara Silva, Daniel Alvarez-Vaca, Celia Aveleira, and Clevio Nobrega

Chapter 31 Roles of Melatonin in Maintaining Mitochondrial Welfare: Focus on Renal Cells...................................389

Feres Jose Mocayar Maron, Emiliano Diez, Russel J. Reiter, and Walter Manucha

Chapter 32 Mitochondrial Dysfunction Affecting the Peripheral Nervous System in Diabetic Neuropathy

and Avenues for Therapy..........................................................................................................................399

Jennifer Jossart, Taylor N. Dennis, and J. Jefferson P. Perry

Chapter 33 Mitochondrial Dysfunction and Oxidative Stress in the Pathogenesis of Metabolic Syndrome................409

Qiaozhu Su and Hao Wang

SECTION IV Immunity and Toxicity

Chapter 34 Regulation of Antiviral Immunity by Mitochondrial Dynamics ..............................................................425

Mohsin Khan, Hasan Imam, and Saiful Anam Mir

Chapter 35 Mitochondrial Dysfunction, Immune Systems, Their Diseases, and Possible Treatments.........................443

Elise Jacquin, Eric Hervouet, and Michael Boyer-Guittaut

Chapter 36 Organophosphorus Compound-Induced Mitochondrial Disruption........................................................461

Alan J. Hargreaves

Chapter 37 Mitochondrial Dysfunction in Friedreich Ataxia .....................................................................................471

Rosella Abeti, Annalisa Baccaro, and Paola Giunti

Index............................................................................................................................................................................477