Our current understanding of a/~ T cell receptor (TCR) ex pressing T cells advanced from function and specificity to the molecular organization ofthe TCR.We now know that the TCR a and ~ chains together express specificity for (antigenic) peptides presented by the "responder" M H C allele, thus explain ing the phenomenon of MHC restriction at a molecular level. Surprisingly even though our perception of the molecular organization of the y5 TCR is well advanced, current knowledge of function and specificity of the y5 T cell subset is poor. There fore it appeared rather timely to bring together scientists pioneering research on y5 T cells forthe International Workshop on Function and Specificity ofy5 Tcells,held October11-14, 1990 at Schloss Elmau/Bavaria, FRG. Besides offering a scientific forum for open discussions, it was also hoped that such a workshop would be seminal for collaborative interactions and personal relationships among scientists "addicted" to y 15 T cells.
Genomic Organization.- Genetic Organization of Human T Cell Receptor Gamma Locus..- Differentiation In Vitro.- Development of Human T Cells Expressing TCR?? In Vitro.- From the Development Expression of ?? T Cell Receptors to the Implications in the Aquisition of Tolerance.- Culture Conditions Dictate Whether Mouse Fetal Thymus Lobes Generate Predominantly ?/? or ?/? T Cells.- Preferential Development of ?/?-Bearing T Cells in Athymic Nude Bone Marrow.- Developmentally Ordered Expression of ?? TCR V?7 Subfamily Genes.- Maturation/ Selection.- Tissue Distribution and Repertoire Selection of Human ?? T Cells: Comparison With the Murine System.- Evidence For Controlled Gene Rearrangements and Cytokine Production During Development of Human TCR??+ Lymphocytes.- Thymic and Extrathymic Development of Human ?/? T Cells.- Differential Effects of Anti-CD3 Antibodies In Vivo and In Vitro on ?? and ?? T Cell Differentiation.- The Beginning and the End of the Development of TCR?? Cells in the Thymus.- Cyclosporin A (CsA) Prevents the Generation of Mature Thymic ?/? T Cells but Spares ?/? T Lymphocytes..- Other Species.- Lack of Alloantigen-Specific Cytotoxic T Cell Activity in the TCR?? T Cell Subpopulation of Alloantigen-Immune Chickens.- Thymic Nurse Cells: A Site for Positive Selection and Differentiation of T Cells.- Marked Variations in ?? T Cell Numbers and Distribution Throughout the Life of Shepp.- ?/? T-Lymphocyte Subsets in Swine.- Transgenic Mice/Manipulation In Vivo.- Mechanisms of Development of ?? T Cell Antigen Receptor-Bearing Cells in ?? T Cell Antigen Receptor Transgenic Mice.- Ligand Specificity and Repertoire Development of Murine TCR?? Cells.- Antigen/ Heat Shock Proteins.- Specificity of Mycobacteria/Self-Reactive ?? Cells.- Modulation of Murine Self Antigens by Mycobacterial Components..- In Vitro Activation of Human ?/? T Cells by Bacteria: Evidence for Specific Interleukin Secretion and Target Cell Lysis..- A Dichotomy Between the Cytolytic Activity and Antigen-Induced Proliferative Response of Human ?? T Cells.- Analysis of Primary T Cell Responses to Intact and Fractionated Microbial Pathogens..- function and Specificity of Human V?9/V?2 T Lymphocytes.- Daudi Cell Specificity Correlates With the Use of aV?9-V?2 Encoded TCR??.- TCT.1: ATarget Structure for a Subpopulation of Human ?/? T Lymphocytes..- Activation and Deactivation of Cloned ?/? T Cells.- ?? T Cells in Leprosy Lesions.- Modifications of ?? T Lymphocytes in the Rheumatoid Arthritis Joint.- Phenotypic and Functional Heterogeneity of Double Negative (CD4-CD8-) ?? TcR+T Cell Clones.- Restriction.- Specificity of Human T Lymphocytes Expressing a ?/? T Cell Antigen Receptor. Recognition of a Polymorphic Determinant of HLA Class I Molecules by a ?/? Clone.- Antigens and Antigen-Presenting Molecules for ?? T Cells.- Correlation Between TCRV Gene Usage and Antigen Specificities in Human ?? T Cells.- Qa-1 Restricted ?? T Cells Can Help B Cells..- CD5 B Cells.- CD5 B Cells in the Mouse.- Mucosal and Dermal Immunity.- Selection ofV?4+T Cell Receptors of Intestinal Intraepithelial Lymphocytes is Dependent on Class II Histocompatibility Antigen Expression..- The Role of Fetal Epithelial Tissues in the Maturation/Differentiation of Bone Marrow-Derived Precursors into Dendritic Epidermal T Cells (DETC) of the Mouse.- Phenotypic and Functional Characterization of Human TCR??+ Intestinal Intraepithelial Lymphocytes..- A Search for Cells Carrying the ?/? T Cell Receptor in Mice Infected with Leishamia major.- Involvement of ?? T Cells in Respiratory Virus Infections..