Bone research in recent years has generated much new knowledge, in large measure because of the broad public health implications of osteoporosis and related bone disorders. Bone Formation, the first in a series entitled Topics in Bone Biology, evaluates this new information and formulates novel insights and hypotheses within the broad framework of current knowledge. An easy-to handle and to read work, with concise reviews that are extensively referenced, the chapters in this book are written by internationally known authorities. Particular emphasis is on osteoporosis and related disorders of diminished bone formation. Among the general topics treated is a chapter on biomechanical aspects of bone formation, not often considered in relation to diseases of bone formation. The book constitutes essential reading for those entering the field of bone biology and those who wish to become familiar with up-to-date information in a particular area of bone research.
Summarizes new knowledge of the many steps that lead to the formation of bone
Contributors are international experts in their field
Contains a chapter on biomechanics – a topic rarely included in books, that emphasizes molecular and cellular aspects
1 Molecular Regulation of Osteoblast Differentiation 2 In Vitro Regulation of Osteoblast Activity 3 Systemic and Local Regulators of Bone Remodeling 4 Site-specific Mineralized Matrix Formation by Osteoblasts 5 Biomechanical Aspects of Bone Formation 6 Reduced Bone Formation in the Pathogenesis of Bone Fragility 7 Diseases of Excess Bone Formation 8 Targeting the Osteoblast for Prevention and Treatment of Bone Diseases