Main description:

A complete update on the safety testing of foods, drugs, and chemicals in laboratory animals, featuring: - a thorough review of each subject area with extensive revision in line with new information and concepts - electron micrographs in exquisite detail to illustrate results of recent research - the effects of many carcinogens described succinctly and illustrated in detail - neoplasms described in detail and compared with natural and induced tumours in other species - standardised nomenclature. Of interest to those interested in the many applications to human patients, Urinary System: - facilitates uniform interpretation of bioassay results world-wide - provides a basis for understanding mechanisms involved in the functions and malfunctions of the most minute, but important structures of the kidneys - explains the functional significance of details by identifying the composition of structures at the molecular level. Forming a solid basis for understanding the causes and effects of disease of the urinary system, this is essential reading for pathologists, toxicologists, regulatory agencies, and all those involved in carcinogenicity and toxicity studies.

Contents:

The Kidney.- Anatomy, Histology, Ultrastructure.- Anatomy, Cytology, Ultrastructure Nephron and Collecting Duct Structure in the Kidney, Rat.- Unique Features of Anatomy, Histology, and Ultrastructure, Kidney, Mouse.- Neoplasms.- Renal Carcinogenesis, Rat.- Oncocytoma, Kidney, Rat.- Renal Cell Adenoma and Carcinoma, Rat.- Mesenchymal Tumor, Kidney, Rat.- Nephroblastoma, Kidney, Rat.- Lipomatous Tumors, Kidney, Rat.- Adenoma, Adenocarcinoma, Kidney, Mouse.- Adenoma, Kidney, Syrian Hamster.- Adenocarcinoma, Kidney, Syrian Hamster.- Angioma, Angiosarcoma, Kidney, Syrian Hamster.- Hereditary Renal Cell Adenoma and Carcinoma, Rat.- Estrogen-Induced Malignant Tumor, Kidney, Golden Hamster.- Non-Neoplastic Lesions.- Immune Mechanisms in Injury to Glomeruli and Tubulointerstitial Tissue.- Spontaneous Renal Amyloidosis, Syrian Hamster.- Chronic Progressive Nephropathy, Rat.- Infarction, Kidney, Rat, Mouse.- Interstitial Nephritis, Mouse.- Suppurative Nephritis, Pyelonephritis, Mouse.- Suppurative Nephritis, Pyelonephritis, Rat.- Chloroform Nephrosis, Male Mouse.- Acute Tubular Lesions, Kidney, Rat.- Juxtaglomerular Cell Hyperplasia, Induced, Laboratory Animals.- Daunomycin-Induced Nephropathy, Rat.- Effect of Experimental Diabetes Mellitus, Kidney, Rat.- Experimental Renal Effects of Analgesics, Rat.- Diphenylthiazole-Induced Renal Cystic Disease, Rat.- Congenital and Inherited Disorders.- Spontaneous Hydronephrosis, Rat.- Nephronophthisis, Mouse.- Parasitic Infections.- Klossiellosis, Kidney, Mouse, Rat.- Renal Pelvis, Ureters, Urinary Bladder, Urethra.- Histology, Ultrastructure.- Histology, Ultrastructure, Urinary Tract, Mouse.- Transitional Epithelium, Bladder, Rat.- Neoplasms.- Hyperplasia, Urinary Bladder, Rat.- Classification and Differential Diagnosis of Neoplasms, Urinary Bladder, Rat.- Carcinogenesis, Urinary Tract, Rat.- Transitional Cell Carcinoma, Bladder, Rat.- Transitional Cell Carcinoma, Urinary Tract, Mouse.- Papilloma, Urinary Bladder, Rat.- Squamous Cell Carcinoma, Urinary Bladder, Rat.- Adenocarcinoma, Urinary Bladder, Rat.- Undifferentiated Carcinoma, Urinary Bladder, Rat.- Induction of Cancer in the Rat Bladder: Pathogenesis, Role of Cell Proliferation, and Relevance to Human Disease.- Submucosal Mesenchymal Tumor, Urinary Bladder, Mouse.- Non-Neoplastic Lesions.- Calcium Oxalate Urolithiasis, Rat.- Urinary Glycoproteins as Modulators of Calcific Nephrolithiasis.- Phosphate Urolithiasis, Rat.- Urologic Syndrome, Mouse.- Parasitic Infections.- Trichosomoides crassicauda Infection, Urinary Bladder, Rat.