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Main description:
These volumes contain the papers which were presented at the Third International Symposium on Purine Metabolism in Man held in Madrid (Spain) in June, 1979. The previous meetings in the series were held in Tel Aviv (Israel) and in Baden (Austria) in 1973 and 1976, respective1y. The proceedings were also published by Plenum. Knowledge of the pathophysio1ogy of the purines has developed greatly since the 1950's when it was main1y re1ated to c1inica1 gout, and it is now relevant to many fie1ds of Medicine and Biology. These volumes include papers reporting new work on clinical gout and uro1ithiasis as we11 as on some of the subjects which have featured prominently in the previous volumes, including: regulatory aspects of the intermediary metabolism of purines and re1ated com- pounds, enzymology, methodology, and the resu1ts of mutations which affect purine metabolism. However, there have been many new develop- ments during the last three years and the scope of the communications reflects not only increasing depth of know1edge, but also a widening of the field.
This publication has clinical and fundamental imp1i- cations for internal medicine, pediatrics, uro1ogy, biochemistry, immunology, genetics, and oncology.
Contents:
of Part A.- I. Clinical Gout.- The Natural History of Hyperuricemia Among Asymptotic Relatives of Patients With Gout.- The Clinical Differentiation of Primary Gout From Primary Renal Disease in Patients With Both Gout and Renal Disease.- Renal Failure in Young Subjects With Familial Gout.- Family Study of Lipid and Purine Levels in Gout Patients and Analysis of Mortality.- Uric Acid Turnover in Normals, in Gout and in Chronic Renal Failure Using 14C-Uric Acid.- Erythrocyte Adenosine-Deaminase Activity in Gout and Hyperuricemia.- Clinical Variability of the Gouty Diathesis.- Clinical Features of 4,000 Gouty Subjects in Japan.- Frequency of Chondrocalcinosis of the Knees and Avascular Necrosis of the Femoral Heads in Gout, a Controlled Study.- Gaschromatographic Evaluation of Urinary 17-Ketosteroids, Etiocholanolone and Dehydroepiandrosterone in Primary Gout and Hyperuricemia.- Hormonal Aspects of Gouty Patients.- Determination of Tubular Secretion of Urate in Healthy and Gouty Men.- Ribose Tolerance in Gouty Patients.- II. Uric Acid and Renal Stones.- Urinary Urate and Uric Acid Relative Saturation in Normouricuric Calcium Oxalate Stone Formers With Normal Urinary Calcium Oxalate Saturation.- Correlation Between the Uric Acid and Calcium Concentration in Urine. Results of a Long Term Study on Recurrent Stone-Formers and Healthy Controls.- Interaction of Hyperuricuria and Hyperoxaluria on Renal Calcium Oxalate Stone Formation.- Uric Acid/Calcium Oxalate Nephrolithiasis. Clinical and Biochemical Findings in 86 Patients.- The Uric Acid: Cystine Correlation in the Urine of Recurrent Calcium Oxalate Stone-Formers and Healthy Controls.- The Role of Urate in Idiopathic Calcium Urolithiasis.- Mineralogic Composition of 66 Mixed Urinary Calculi of Calcium Oxalate and Uric Acid.- Hyperuricemia and Cystinuria.- Monosodium Urate Monohydrate as Spherulites.- III. Clinical and Physiological Aspects of Purine Metabolism.- Tumoural Hypouricemia.- Hereditary Renal Hypouricemia With Hyperuricosuria and Variably Absorptive Hypercalciuria and Urolithiasis - A New Syndrome.- Hereditary and Environmental Factors Influencing on the Serum Uric Acid Throughout Ten Years Population Study in Japan.- The Natural History of Urate Overproduction in Sickle Cell Anemia.- Salvage Pathway in Erythrocytes of Patients With Psoriasis.- Serum 5-Nucleotidase in Progressive Muscular Dystrophy.- Purine Metabolism in Duchenne Muscular Dystrophy.- Metabolism of Adenine and Adenosine in Erythrocytes of Patients with Myotonic Muscular Dystrophy (MMD).- Clinical and Enzymological Studies in a Child With Type I Glycogen Storage Disease Associated With Partial Deficiency of Hepatic Glucose-6-Phosphatase.- Differential Absorption of Purine Nucleotides, Nucleosides and Bases.- Influence of Dietary Protein on Serum and Urinary Uric Acid.- Effect of Hypoxanthine in Meat on Serum Uric Acid and Urinary Uric Acid Excretion.- On the Mechanism of the Paradoxical Effect of Salicylate on Urate Excretion.- The Uricosuric Action of Protein in Man.- Hypoxic Effects on Purine Metabolism Studied With High Pressure Liquid Chromatography.- Urate Metabolism in a Mongrel Dog.- IV. Studies on Xanthinuria.- The Effect of Weight Reduction on Plasma and Urinary Levels of Oxypurines in an Obese Xanthinuric Patient.- Xanthinuria: The Cause of Hypouricemia in Hepatic Disease.- Xanthine-Coproporphyrin III.- V. Therapeutical Aspects of Disorders in Purine Metabolism.- A Controlled Study of the Effect of Long Term Allopurinol Treatment on Renal Function in Gout.- Studies With Allopurinol in Patients With Impaired Renal Function.- Pharmacological Effects of 1,3,5-Triazines and Their Excretion Characteristics in the Rat.- Tienilic Acid in the Treatment of Gout and Hypertension.- Benzbromarone as a Long-Term Uricosuric Agent.- The Action of Benzbromarone in Relation to Age, Sex and Accompanying Diseases.- Covalitin (R): A New Drug for the Treatment of Uric Lithiasis.- VI. Mutations Affecting Purine Metabolism.- A. Phosphoribosyltransferases.- Hypoxanthine Salvage in Man: Its Importance in Urate Overproduction in the Lesch-Nyhan Syndrome.- Aspect of Purine Metabolic Aberration Associated With Uric Acid Overproduction and Gout.- Properties of a Mutant Hypoxanthine-Phosphoribosyltransferase in a Patient With Gout.- Variation in Human HPRT and Its Relationship to Neurologic and Behavioral Manifestations.- High HPRT Activity in Fibroblasts from Patients With Lesch-Nyhan Syndrome due to Bacterial "L-Form" Contamination.- Kinetics of a HGPRT Mutant Showing Substrate Inhibition.- B. Nucleoside Phosphoribosylating Enzymes.- Spectrum of 2,8-Dihydroxyadenine Urolithiasis in Complete APRT Deficiency.- Complete Adenine Phosphoribosyltransferase (APRT) Deficiency in Two Siblings: Report of a New Case.- Inheritance of Adenine Phosphoribosyltransferase (APRT) Deficiency.- Immunological Evaluation of a Family Deficient in Adenine Phosphoribosyl Transferase (APRT).- Activities of Amidophosphoribosyltransferase and Purine Phosphoribosyltransferases in Developing Rat Brain.- Purine Nucleoside Phosphorylase Deficiency; Genetic Studies in a Dutch Family.- C. Nucleoside Cleaving Enzymes.- Abnormal Regulation of Purine Metabolism in a Cultured Mouse T-Cell Lymphoma Mutant Partially Deficient in Adenylosuccinate Synthetase.- Superactive Phosphoribosylpyrophosphate Synthetase With Altered Regulatory and Catalytic Properties.- AMP Phosphatase Activity in Human Term Placenta: Studies on Placental 5?-Nucleotidase.- D. Deaminating Enzymes.- Adenosine and Deoxyadenosine Metabolism in the Erythrocytes of a Patient With Adenosine Deaminase Deficiency.- Complete Adenosine Deaminase (ADA) Deficiency Without Immunodeficiency, and Primary Hyperoxaluria, in a 12-Year-Old Boy.- Metabolism of Adenosine and Deoxyadenosine by Stored Human Red Cells.- Adenosine Deaminase and Purine Nucleoside Phosphorylase Activities During Culturing of Fibroblasts.- S-Adenosylhomocysteine Metabolism in Adenosine Deaminase Deficient Cells.- Altered Deoxynucleoside Triphosphate Levels Paralleling Deoxyadenosine Toxicity in Adenosine Deaminase Inhibited Human Lymiphocytes.- Author Index.
PRODUCT DETAILS
Publisher: Springer (Springer-Verlag New York Inc.)
Publication date: November, 2012
Pages: 444
Weight: 801g
Availability: Available
Subcategories: Biochemistry, Immunology, Oncology
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