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Main description:
Numerous studies have pointed to the key role of complement in the pathogenesis of retinal disease, particularly age-related macular degeneration (AMD). Reports about new gene associations and links to other physiological pathways are emerging almost on a weekly base. Several promising clinical candidates covering a wide area of potential treatment applications are in the pipelines of both industrial and academic groups. This indicates an increasing interest in complement as a therapeutic target. In view of these exciting discoveries, scientists from around the world convened at the First Aegean Conferences Conference on Inflammation and Retinal Disease: Complement Biology and Pathology (June 10-17, 2007) in Crete, Greece, to discuss recent advances in this rapidly-evolving field. This volume represents a collection of topics on the functions of complement in eye diseases, pathophysiology, protein structures, and complement therapeutics discussed during the conference. Our sincere thanks to the contributing authors for the time and effort they have devoted to writing what I consider exceptionally informative chapters in a book that will have a significant impact on the complement field. We would also like to express my thanks to Rodanthi Lambris for her assistance in collating the chapters and preparing the documents for publication and I gratefully acknowledge the generous help provided by Dimitrios Lambris in managing the organization of this meeting. Finally, I also thank Andrea Macaluso of Springer Publishers for her supervision in this book's production. John D. Lambris Anthony P.
Contents:
Preface
Contributors
1. The Case for Complement and Inflammation in AMD: Open Questions
Natalia Karagianni and Anthony P. Adamis
Abstract
1. Introduction
2 Drusen
3. Geographic Atrophy
4. Choroidal Neovascularization
References
2. The Role of Complement in AMD
Peter F. Zipfel, Nadine Lauer and Christine Skerka
Abstract
1 Age-related macular degeneration
1.1 The disease
1.2 AMD - a chronic inflammatory disease
2 Age-related macular degeneration - a genetic disorder
3 Effect of the reported SNPs for protein function
3.1 Factor H and other Complement Proteins
3.1.1 Factor H and FHL1
3.1.2 Complement Factor H related proteins (CFHRs)
3.1.3 Other Complement proteins associated with AMD: C2, Factor B and C3
3.2. Gene products of the chromosome 10q26: ARMS-2 and HRTA1
4 Lessons learned from rare disorders (HUS, MPGN)
5 Outlook
References
3. Multiple interactions of complement factor H with its ligands in solution: a progress report
Stephen J Perkins, Ruodan Nan, Azubuike I. Okemefuna, Keying Li, Sanaullah Khan and Ami Miller
Abstract
1. Complement Factor H
2. Structure of Factor H
3. Self-association of Factor H
5. Interaction of Factor H with C-reactive protein
6. Interaction of Factor H with heparin
7. Interaction of Factor H with C3d
8. Conclusions and Future Considerations
References
4. Genetic Control of Complement Activation in Humans and Age Related Macular Degeneration
Laura A. Hecker, and Albert O. Edwards
Abstract
1.Genes associated with AMD
2. Non-genetic factors increasing the risk of AMD
3. Complement proteins and AMD
4. Conclusions
References
5. Bisretinoids of RPE Lipofuscin: Trigger for Complement Activation in Age-Related Macular Degeneration
Janet R. Sparrow
Abstract
1 RPE Lipofuscin and Macular Degeneration
2 Age-related Macular Degeneration and the Complement System
3 Complement Activation by Photoproducts of the RPE Bisretinoid A2E
4 Complement Activation by Oxidized all-trans-retinal-dimer
5 Complement Activation by BisretinoidPhotoproducts is Dependent on Factor B
6 C-Reactive Protein Modulates Complement Activation by RPE Bisretinoids
7 Suppression by POT-3, a C3 Cleavage Inhibitor
8 Summary
9 Acknowledgements
References
6. The Role of the Classical Complement Cascade in Synapse Loss during Development and Glaucoma
Allison M Rosen and Beth Stevens
Abstract
1 Introduction
2 Current Opinion on Glaucoma
3 Animal models of glaucoma
4 Pathological progression of glaucoma
5 Role of Glial Activation in Glaucoma
6 Inflammation and enhanced cytokine production in glaucoma
7 Complement Cascade Upregulation and Activation in Glaucoma
8 Parallels between Complement-mediated Synapse Elimination and Synapses
9 Conclusions and Perspecitves
Acknowledgment
References:
7. A Role for Complement in Glaucoma?
Lizhen Ren, John Danias
Abstract
1 Introduction
2 Complement and glaucoma
8. The ATP-binding Cassette Transporter ABCA4: Structural and Functional Properties and Role in Retinal Disease
Yaroslav Tsybovsky, Robert S. Molday and Krzysztof Palczewski
Abstract
1 Introduction to ABC Transporters
2 Human ABC Transporters
3 ABCA4 and Vision Diseases
4 Molecular View of ABCA4
4.1 Primary Structure
4.2 Localization
4.3 Insights into Topology, Structure and Posttranslational Modifications
4.4 Structural Features of Individual Domains
5 Biological Role of ABCA4
5.1 Identification of Substrate: Biochemical Evidence
5.2 Proposed General Model of Transport
5.3 Abca4 Knockout Mice
5.4 Proposed Role of ABCA4 in the Visual Cycle
5.5 Unresolved Issues
6 ABCA4 Mutations and Autosomal Recessive Macular Degeneration
7 Conclusions
References
9. Suppression of Drusen Formation by Compstatin, a Peptide Inhibitor of Complement C3 activation, on Cynomolgus Monkey with Early-Onset Macular Degeneration
Zai-Long Chi, Tsunehiko Yoshida, John Lambris, and Takeshi Iwata
Abstract
1 AMD and association of complement related genes
2 Activated complement component in drusen
3 Cynomolgus monkey with early-onset macular degene
PRODUCT DETAILS
Publisher: Springer (Springer-Verlag New York Inc.)
Publication date: October, 2012
Pages: 180
Weight: 290g
Availability: Available
Subcategories: Ophthalmology and Optometry
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