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Main description:
The Conference "Chemical and Immunologic Approaches to the Cell Surface" was organized as a multifaceted interaction between scientists representing various disCiplines impinging on membrane bio- logy. In many instances, this broad mixture of investigators yielded quite unusual scientific associations and interesting new dimensions to old prob- lems, as the workers came to appreciate the advallces, the shortcomings, and the hurdles of each area. Structural concepts of the membrane--the nature, orientation, and inter-relationship of components--are emerging primarily from work on erythrocytes. Our understanding of surface biology demands reconstruc- tion from the meager, but rapidly emerging, structural information. The excitement of membrane research depends in no small part on the concept that membranes are not static crystalline structures but rather dynamic systems with variable interrelationships between mUltiple components and phases, reflecting external environmental and internal cellular events.
Modulation of the membrane can be readily studied in systems where dis- crete pertubation is introduced into the surface structure by stimulation with mitogens or reactions of immunoglobulins, reSUlting in wide-ranging effects. Examination of sequential changes such as patching and capping, in intact cells or in artificially reconstituted lipide, or lipide-protein, membrane systems probably represent useful iatrogeniC probes to mimic genuine in vivo biophysical phenomena related to the mobility, cooperative- ly and constraint of surface components.
Contents:
I.J Structure and Orientation of Surface Molecules.- II. Solubilization and Expression of Surface Components.- III. Modulation of Cell Surface Structure and Function.- IV. Biological Activities of Solubilized Cell Surface Components.- V Perspective of Cell Surface Structure and Function.- Conferees.
PRODUCT DETAILS
Publisher: Springer (Springer-Verlag New York Inc.)
Publication date: November, 2012
Pages: 280
Weight: 559g
Availability: Available
Subcategories: Biochemistry
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