(To see other currencies, click on price)
MORE ABOUT THIS BOOK
Main description:
Malaria is a major infectious disease, affecting 500 million people and causing the death of around two million people each year. As the parasite becomes resistant to available drugs there is an urgent need to uncover new therapies that will protect against and cure this debilitating and fatal disease. Knowledge of specific physiological and biochemical processes in the malaria–infected erythrocyte could provide a basis for the development and targeting of such drugs. This book offers insights into three interrelated aspects of the malaria–infected erythrocyte:
- The transport of solutes into and out of the infected cell and the use of specific trafficking pathways in drug targeting.
- The traffic of proteins produced by the intracellular parasite as an essential process for the biogenesis of transport systems.
- The relationship between the transport of drugs into the infected cell and the mode of drug action and drug resistance.
Back cover:
Malaria is a major infectious disease, affecting 500 million people and causing the death of around two million people each year. As the parasite becomes resistant to available drugs there is an urgent need to uncover new therapies that will protect against and cure this debilitating and fatal disease. Knowledge of specific physiological and biochemical processes in the malaria–infected erythrocyte could provide a basis for the development and targeting of such drugs. This book offers insights into three interrelated aspects of the malaria–infected erythrocyte:
- The transport of solutes into and out of the infected cell and the use of specific trafficking pathways in drug targeting.
- The traffic of proteins produced by the intracellular parasite as an essential process for the biogenesis of transport systems.
- The relationship between the transport of drugs into the infected cell and the mode of drug action and drug resistance.
Contents:
Introduction: host–parasite interrelations in the genomic age
H. GINSBURG
Erythrocyte membrane transport
Z. I. CABANTCHIK
Chemical and physical in vitro alterations of the erythrocyte membrane: a model for its pathophysiological states?
B. DEUTICKE
The effects of transport perturbations on the homeostasis of red blood cells
V. LEW and A.R. HOCKADAY
Transport properties of the host cell membrane
K. KIRK, H.M. STAINES, R.E. MARTIN and K.J. SALIBA
Transport of phospholipid synthesis precursors and lipid trafficking into malaria–infected erythrocytes
H.J. VIAL, P. ELDIN, D. MARTIN, L. GANNOUN, M. CALAS and M.L. ANCELIN
A nutrient–permeable channel on the intraerythrocytic malaria parasite
S.A. DESAI
The permeability properties of the parasite cell membrane
H. GINSBURG
Macromolecular transport in malaria–infected erythrocytes
T. F. TARASCHI
Expression of parasite transporters in Xenopus oocytes
S. KRISHNA and C.J. WOODROW
Reconstitution of protein transport across the vacuolar membrane in Plasmodium falciparum–infected permeabilized erythrocytes
S. BAUMEISTER, A. BURGWEDEL, U.–G. MAIER and K. LINGELBACH
Export of parasite proteins to the erythrocyte cytoplasm: secretory machinery and signalling motifs
F.R. ALBANO, M. FOLEY and L. TILLEY
Transport and trafficking: Toxoplasma as a model for Plasmodium
D.S. ROOS, M.J. CRAWFORD, R.G.K. DONALD, L.M. FOHL, K.M. HAGER, J.C. KISSINGER, M.G. REYNOLDS, B. STREIPEN and W.J. SULLIVAN Jr
An alternative secretory pathway in Plasmodium: more questions than answers
M.F. WISER, D.J. GRAB, and H.N. LANNERS
The transport of the histidine–rich protein I from Plasmodium falciparum is insensitive to brefeldin A
D. MATTEI, L. BERRY, S. COUFFIN and O. RICHARD
Protein transport in the host cell cytoplasm and ATP–binding cassette proteins in Plasmodium falciparum–infected erythrocytes
Z. BOZDECH and E. SCHURR
Chloroquine uptake and activity is determined by binding to ferriprotoporphyrin IX in Plasmodium faciparum
P.G. BRAY, O. JANNEH and S.A. WARD
Chloroquine uptake, altered partiitioning and the basis of drug resistance: evidence for chloride dependent ionic regulation
J.A. MARTINEY, A.S. FERRER, A. CERAMI, S. DZEKUNOV and P. ROEPE
PRODUCT DETAILS
Publisher: John Wiley & Sons Ltd (Wiley–Blackwell)
Publication date: September, 2007
Pages: 304
Dimensions: 156.00 x 235.00 x 19.00
Weight: 580g
Availability: Not available (reason unspecified)
Subcategories: Diseases and Disorders
From the same series
CUSTOMER REVIEWS
"...an excellent reference work for those in the field..." (Cell Biology International, Vol.26, No. 4, 2002)