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Main description:
Clinical Applications of TGF–ß Chairman: M.B. Sporn 1991 TGF–ß, originally identified as a transforming growth factor, is now known to exist as a family of factors with similar properties. These factors promote cell proliferation in some tissue types or conditions and induce cell differentiation in others. This book contains the latest information on the molecular biology of this family and the cognate receptors. TGF–ß regulates the expression of components of the extracellular matrix, and thus cell adhesion and migration processes that are particularly important during development and tumorigenesis. TGF–ß has an effect on many cell types, which means that it, or its antagonists, may have clinical applications in diseases of many different tissues. It is already showing promise as a therapeutic agent in bone and wound healing. Increased expression of TGF–ß is associated with the fibrosis that occurs in chronic liver disease (TGF–ß1) and in pulmonary fibrosis of the lung (TGF–ß1 and 2). Treatment with an anti–TGF–ß1 antiserum attenuated the histological manifestations of disease in an experimental model of glomerulonephritis. In the haemopoietic system, TGF–ß arrests the growth of the most primitive stem cells and could therefore be used as a bone marrow protrctive agent during chemotherapy. In contrast, TGF–ß2 is produced by glioblastomas and may contribute to the malignancy of these tumours by impairing tumour surveillance another case in which treatment with an antagonist may be useful. The complex effects of TGF–ß in different tissues make it a very exciting agent, but one which must be used with care. This book evaluates the behaviour of the TGF–ß family in many contexts and provides a basis for future clinical application. Other Ciba Foundation Symposia: No 143 The biology of hyaluronan Chairman: T.C. Laurent 1989 ISBN 0 471 92305 2 No 148 Molecular control of haemopoiesis Chairman: D. Metcalf 1990 ISBN 0 471 92561 6 No 150 Proto–oncogenes in cell development Chairman: T. Hunter 1990 ISBN 0 471 92686 8
Back cover:
Clinical Applications of TGF–ß Chairman: M.B. Sporn 1991 TGF–ß, originally identified as a transforming growth factor, is now known to exist as a family of factors with similar properties. These factors promote cell proliferation in some tissue types or conditions and induce cell differentiation in others. This book contains the latest information on the molecular biology of this family and the cognate receptors. TGF–ß regulates the expression of components of the extracellular matrix, and thus cell adhesion and migration processes that are particularly important during development and tumorigenesis. TGF–ß has an effect on many cell types, which means that it, or its antagonists, may have clinical applications in diseases of many different tissues. It is already showing promise as a therapeutic agent in bone and wound healing. Increased expression of TGF–ß is associated with the fibrosis that occurs in chronic liver disease (TGF–ß1) and in pulmonary fibrosis of the lung (TGF–ß1 and 2). Treatment with an anti–TGF–ß1 antiserum attenuated the histological manifestations of disease in an experimental model of glomerulonephritis. In the haemopoietic system, TGF–ß arrests the growth of the most primitive stem cells and could therefore be used as a bone marrow protrctive agent during chemotherapy. In contrast, TGF–ß2 is produced by glioblastomas and may contribute to the malignancy of these tumours by impairing tumour surveillance another case in which treatment with an antagonist may be useful. The complex effects of TGF–ß in different tissues make it a very exciting agent, but one which must be used with care. This book evaluates the behaviour of the TGF–ß family in many contexts and provides a basis for future clinical application. Other Ciba Foundation Symposia: No 143 The biology of hyaluronan Chairman: T.C. Laurent 1989 ISBN 0 471 92305 2 No 148 Molecular control of haemopoiesis Chairman: D. Metcalf 1990 ISBN 0 471 92561 6 No 150 Proto–oncogenes in cell development Chairman: T. Hunter 1990 ISBN 0 471 92686 8
Contents:
Partial table of contents:
Multiple Forms of TGF– : Distinct Promoters and Differential Expression (A. Roberts, et al.).
Mechanisms in TGF– Action (J. Massagué, et al.).
Regulation of Epithelial Proliferation by TGF– (H. Moses, et al.).
Latent Forms of TGF– : Molecular Structure and Mechanisms of Action (K. Miyazono & C. Heldin).
TGF– : A Possible Autocrine Immune Regulator (C. Lucas, et al.).
TGF– and Wound Healing (E. Amento & L. Beck).
The Effects of TGF– on Bone (G. Mundy).
Effects of TGF– s in the Liver: Cell Proliferation and Fibrogenesis (N. Fausto, et al.).
Role of TGF– 1 in Experimental Glomerulonephritis (W. Border, et al.).
In Vivo and in Vitro Effects of TGF– 1 on Normal and Neoplastic Hemopoiesis (F. Ruscetti, et al.).
Expression of TGF– 2 in Human Glioblastoma: A Role in Resistance to Immune Rejection?
(A. Fontana, et al.).
Index of Contributors.
Subject Index.
PRODUCT DETAILS
Publisher: John Wiley & Sons Ltd (Wiley–Blackwell)
Publication date: September, 2007
Pages: 264
Dimensions: 135.00 x 255.00 x 10.00
Weight: 530g
Availability: Not available (reason unspecified)
Subcategories: Diseases and Disorders
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