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MORE ABOUT THIS BOOK
Main description:
Several neurotrophic factors have been shown to promote the growth, survival and differentiation of neurons. This book brings together laboratory investigators and scientists involved in clinical trials to discuss the potential therapeutic use of these growth factors. Included are details of several trials currently underway involving growth factors as treatments for neurological disorders such as amyotrophic lateral sclerosis, Alzheimer′s Disease, post–polio syndrome and diabetic and drug–induced neuropathies. The relatively rapid pace at which neurotrophic factors are being brought into the clinical arena raises important questions involving scientific, practical and ethical issues: these are discussed. The book also looks at the latest animal studies examining the potential use of growth factors for promoting regrowth of nerves innervating sensory receptors in the eye, nose and ear. Finally, the technical problems of using growth factors as drugs are discussed. Various approaches to the problem of neurotrophin delivery are considered in detail, including new approaches based on the implantation of genetically engineered cells.
Back cover:
Several neurotrophic factors have been shown to promote the growth, survival and differentiation of neurons. This book brings together laboratory investigators and scientists involved in clinical trials to discuss the potential therapeutic use of these growth factors. Included are details of several trials currently underway involving growth factors as treatments for neurological disorders such as amyotrophic lateral sclerosis, Alzheimer′s Disease, post–polio syndrome and diabetic and drug–induced neuropathies. The relatively rapid pace at which neurotrophic factors are being brought into the clinical arena raises important questions involving scientific, practical and ethical issues: these are discussed. The book also looks at the latest animal studies examining the potential use of growth factors for promoting regrowth of nerves innervating sensory receptors in the eye, nose and ear. Finally, the technical problems of using growth factors as drugs are discussed. Various approaches to the problem of neurotrophin delivery are considered in detail, including new approaches based on the implantation of genetically engineered cells.
Contents:
Partial table of contents:
Motor Neuron Disease and Model Systems: Aetiologies, Mechanisms and Therapies (D. Price, et al.).
Potential Utility of rhIGF–1 in Neuromuscular and/or Degenerative Disease (J. Vaught, et al.).
Development of Neurotrophic Factor Therapy for Alzheimer′s Disease (F. Hefti, et al.).
Somatic Gene Therapy for Nervous System Disease (M. Tuszynski & F. Gage).
Neurotrophic Factors in the Treatment of Peripheral Neuropathy (S. Apfel & J. Kessler).
Growth Factors in the Treatment of Degenerative Retinal Disorders (T. Reh, et al.).
Growth Factors as Potential Drugs for the Sensory Epithelia of the Ear (J. Corwin, et al.).
The Problems of Delivering Neuroactive Molecules to the CNS (S. Tan & P. Aebischer).
Closing Remarks (J. Kessler).
Indexes.
PRODUCT DETAILS
Publisher: John Wiley & Sons Ltd (Wiley–Blackwell)
Publication date: September, 2007
Pages: 264
Dimensions: 156.00 x 235.00 x 10.00
Weight: 525g
Availability: Not available (reason unspecified)
Subcategories: Diseases and Disorders
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