This collection of current and future concepts of neovascularization offers fascinating insights into refining a powerful therapeutic tool which has not yet had the chance to live up to the expectations and needs of the medical community. It examines current refinements in the fundamental concept of neovascularization and describes the most recent developments, which in the future might pave the way towards a new era of therapeutic applications.
Cutting edge science
Comprehensive status report
Leaders in the field
Part 1: The clinical challenge Chapter 1: Clinical vascular growth factor therapy for neovascularization in patients with coronary artery disease by Jens Kastrup Chapter 2: The strengths and weaknesses of VEGF adenovirus-driven angiogenesis by Petra Korpisalo, Tuomas Rissanen, Seppo Ylä-Herttuala Chapter 3: Angiogenesis and arteriogenesis in diabetes mellitus: Signal transduction defects as the molecular basis of vascular cell dysfunction by Vadim Tchaikovski, Johannes Waltenberger Chapter 4: Endothelial activation and enointimal hyperplasia: A double edged sword by Rohit Khurana, Michael Simons Part 2: Novel mechanical and molecular concepts Chapter 5: Pampering and priming the heart by Mark Post, Roberte Cornelussen and Fritz Prinzen Chapter 6: Coronary venous retroinfusion: a novel venue of regional induction of neovascularization by Peter Boekstegers and Christian Kupatt Chapter 7: Integrative Pro-angiogenic Activation: HIF-1a by Karen Vincent and Ralph Kelly Chapter 8: The maturation of vessels – a limitation to forced neovascularization? by Andrea Banfi, Philipp Fueglistaler and Roberto Gianni-Barrera Chapter 9: Vascular and neuronal development: intersecting parallelisms and crossroads by Serena Zacchigna, Carmen Ruiz de Almodovar, Peggy Lafuste and Peter Carmeliet Chapter 10: Cathelicidin antimicrobial peptides modulate angiogenesis by Rembert Koczulla and Robert Bals Part 3: Cell therapy as an option Chapter 11: The biology of embryonic and adult endothelial progenitor cells by Mathias Lamparter and Antonis Hatzopoulos Chapter 12: Signaling behind progenitor cell mobilization: focus on eNOS and caveolin by Olivier Feron Chapter 13: The role of monocytes/macrophages and vascular resident precursorcells in collateral growth by Wulf Ito