Main description:

This book is a comprehensive and up-to-date compendium on all aspects of sarcomas of bone and soft tissues in childhood and adolescence. After introductory chapters on the history, epidemiology, and biology of pediatric sarcomas, treatment considerations are extensively reviewed, with emphasis on the use of risk-adjusted treatment approaches. The pathology and biology of this diverse group of tumors are extensively reviewed. Promising new treatment approaches are discussed, and strategies for the development of new agents are appraised. The major common pediatric sarcomas, including osteosarcoma, Ewing sarcoma, rhabdomyosarcoma and non-rhabdomyosarcoma soft tissue sarcoma, are covered in detail. The authors are internationally recognized experts who offer a largely evidence-based consensus on etiology, biology, and treatment. This handbook has far-reaching applicability to the clinical diagnosis and management of childhood and adolescent sarcomas and will prove invaluable to specialists, generalists, and trainees alike.

Contents:

Multi-Institutional Trials for Patients with Rhabdomyosarcoma: Lessons from North American Studies from 1967 through 1997.- Epidemiology of Bone and Soft Tissue Sarcomas.- Sarcoma Pathology and Biology.- Experimental Models.- Staging and Imaging of Sarcoma.- Rhabdomyosarcoma.- Current Approaches to Therapy: Soft Tissue Sarcomas Other Than Rhabdomyosarcoma in Children and Adolescents.- Approach to therapy: Osteosarcoma.- Contemporary Approach to Therapy for Ewing Sarcoma.- Strategies for New Agent Development in Pediatric Sarcomas.- Immunotherapy for Pediatric Sarcomas.