Main description:

Over the past few decades technological advances in transcriptomics, proteomics, metabolomics, and glycomics along with the ability to selectively knockout genes of interest has greatly advanced our understanding of maternal-conceptus interactions that are essential for the establishment and maintenance of a successful pregnancy. This knowledge provides a foundation from which to build research endeavors to help resolve infertility, embryonic loss and recurrent abortion in humans, captive wild animals and important farm species. The present volume on "Regulation of Implantation and Establishment of Pregnancy in Mammals" brings together current reviews from leading experts to address the diversity of mechanisms by which species establish and maintain pregnancy. Implantation in rodents, dogs, pigs, cattle, sheep, horses, primates, humans and embryonic diapause in wild species are discussed. Reviews will provide current knowledge on the role of endometrial steroid receptors, adhesion factors, cytokines, interferons, steroids, prostaglandins, growth factors and immune cells involved with regulation of conceptus development.

Contents:

Introduction -Rodney Geisert.- History of Maternal Recognition of Pregnancy - Fuller W. Bazer.- The Role of Steroids Hormone Receptors in the Establishment of Pregnancy in Rodents - Nyssa R. Adams and Francesco J. DeMayo.- Transmembrane Mucin Expression and Function in Embryo Implantation and Placentation - Pamela E. Constantinou, Micaela Morgado and Daniel D. Carson.- Reflections on Rodent Implantation - Jeeyeon M. Cha and Sudhansu K. Dey.- The Role of Progesterone in Maternal Recognition of Pregnancy in Domestic Ruminants - Pat Lonergan and Niamh Forde.- Implantation and Establishment of Pregnancy in Ruminants - Thomas E. Spencer and Thomas R. Hansen.- Implantation and Establishment of Pregnancy in the Pig - Rodney D. Geisert, Gregory A. Johnson and Robert C. Burghardt.- Pregnancy Recognition and Implantation of the Conceptus in the Mare - Claudia Klein.- Implantation and Establishment of Pregnancy in Human and Non-Human Primates - Ren-Wei Su and Asgerally T. Fazleabas.- The Dog: Nonconformist, Not Only In Maternal Recognition Signaling - Mariusz P. Kowalewski, Aykut Gram, Ewa Kautz, Felix Graubner.- Embryonic Diapause and Maternal Recognition of Pregnancy in Diapausing Mammals - Marilyn B. Renfree.- Predicting Embryo Presence and Viability - Ky G. Pohler, Jonathon A. Green, Thomas W. Geary, R.F.G. Peres, M.H.C. Pereira, J.L.M. Vasconcelos and M.F. Smith.- Subject Index.