Over the past few decades health-related quality of life (HRQL) has emerged as the new image of medicine viewed from a psychosocial perspective. The concept of Quality of Life has attracted a good deal of interest, not only from a clinical perspective but also from psychosocial, health economics as well as cultural aspects. More recently, the neurobiological brain substrates that modulate many aspects of subjective experiences, which is relevant to quality of life such as affect, mood, cognition, pleasure, reward responses as well as feeling of wellbeing and satisfaction has been explored and elucidated. Such increased interest in HRQL is highlighted by the large number of recent publications. Over the past 10 years at least 350 papers were published describing aspects of HRQL in the psychiatric and mental field. Among them 78% dealt with HRQL in schizophrenia and schizoaffective disorders, 21% with major depression, 14% with anxiety disorders and 4% with bipolar disorder. It is gratifying to witness the enhanced interest and popularity in HRQL research and publications, yet the field continues to suffer from conceptual inconsistencies as well as a good deal of methodological limitations. It is worrisome that we still do not have a clear understanding of the concept itself as applied to mental health and illness as well as the complex array of its determinants. Similarly there is a lag in the application of quality of life data in improving clinical practice.
The Distress/Protection Vulnerability model of HRQL impairment
New insights from neuroscience
Integrative approach to quality of life measurement
Comparative data regarding severe mental disorders
Treatment and Rehabilitation Issues
Contributors; Foreword; Part One Key Methodological Issues 1. The Distress/Protection Vulnerability Model of the quality of life impairment syndrome: current evidence and new directions for research, Ritsner MS; 2. Role of dopamine in pleasure, reward and subjective responses to drugs: the neuropsychopharmacology of quality of life in schizophrenia, Voruganti L.N.P., and Awad A.G.; 3. Neuroendocrine functions, mood and quality of life, Mazza, M., and Mazza, S; 4. In the Eyes of the Beholder: Neuronal mediators for the effect of emotional experience on quality of life, Hendler T, Admon R., and Papo D.; 5. Cross-cultural quality of life research in mental health: conceptual approaches, assessment strategies, empirical results and potential impact, Bullinger M, Schmidt S, and Naber D.; 6. Measuring the value of health-related quality of life, Hawthorne G; 7. Comparison of instruments for measuring quality of life impairment syndrome in severe mental disorders: Q-LES-Q versus QLS and LQOLP, Ritsner MS; 8. Integrative bottom-up approach to quality of life measurement, Pukrop R and Bechdolf A; Part Two Quality of Life Impairment Syndrome in Severe Mental Disorders 9. Health related quality of life in subjects at risk for a first episode of psychosis, Bechdolf, A., Veith, V, Pukrop, R., Klosterkötter J; 10. Quality of life impairment syndrome in schizophrenia, Ritsner MS and Gibel A; 11.Insight and quality of life in schizophrenia spectrum disorders: An examination of their paradoxical relationship, Lysaker PH, and Louanne D; 12. Quality of life and major depression: current findings and future perspectives, Berlim MT, and Fleck MPA; 13. Quality of life impairment in bipolar disorder, Michalak EE, Murray G, Young AH and Lam RW; 14. Quality of life impairment in anxiety disorders, Koury MA and Rapaport MH; 15. Quality of life in in obsessive-compulsive disorder, Bobes J, García-Portilla MP, Bascaran M-T, Saiz P-A, Bobes-Bascaran M-T,Bousoño M; Part Three Treatment and Rehabilitation Issues 16. Antipsychotic medications, schizophrenia and the issue of quality of life, Awad A.G., and Voruganti L.N.P.; 17. Quality of life outcomes of ECT, Rosenquist PB, and McCall WV.; 18. Quality of life in mental health services, Evans S.; 19. Subjective quality of life in relation to psychiatric rehabilitation and daily life, Eklund M.; 20. Cost-utility analysis: research and practical applications, Dernovsek MZ, Rupel VP, and Tavcar R.; INDEX.