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Prions and Diseases
Volume 1, Physiology and Pathophysiology
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Main description:

Volume I highlights the association of the cellular prion protein (PrPC) with copper and zinc, the potential roles of PrPC in Alzheimer’s disease and cancers, insoluble PrPC, PMCA, molecular and cellular mechanisms of PrPSc formation and clearance, possible co-factors involved in the conversion of PrPC into PrPSc, infectious and pathogenic forms of PrP, cell biology of prions, prion strains and their interference, as well as yeast prions and their inheritable and structural traits. This unique volume will take you through the fascinating chronicle of prions in mammals, yeast, and fungi.


Feature:

Authored by a team of leading researchers and clinicians

Updated knowledge and concepts on pathogenic prion proteins and prion diseases

Present state-of the art findings and hypotheses beyond prions and prion diseases


Back cover:

Transmissible spongiform encephalopathies (TSE), now broadly known as prion diseases, have been recognized for nearly 300 years in animals and almost 100 years in humans. However, the nature of the transmissible agent had largely remained a mystery until Stanley Prusiner discovered the infectious isoform of the prion protein (PrP), named prion or scrapie PrP (PrPSc), in 1982. The subsequent modern studies with protein chemistry and molecular biology in cell culture, transgenic animals, and cell-free systems, including the revolutionary protein-misfolding cyclic amplification (PMCA), have greatly advanced our understanding of the pathogenesis of prion diseases and facilitated the identification of new prion diseases in animals and humans. In Prions and Prion Diseases, more than 60 leading researchers and clinicians worldwide provide an up-to-date development in many aspects of these unique infectious pathogens and their associated diseases.

Volume I highlights the association of the cellular prion protein (PrPC) with copper and zinc, the potential roles of PrPC in Alzheimer’s disease and cancers, insoluble PrPC, PMCA, molecular and cellular mechanisms of PrPSc formation and clearance, possible co-factors involved in the conversion of PrPC into PrPSc, infectious and pathogenic forms of PrP, cell biology of prions, prion strains and their interference, as well as yeast prions and their inheritable and structural traits. This unique volume covers history from the high Middle Ages to the TSE era of Daniel Carleton Gajdusek, followed by the prion era of Stanley Prusiner whose extraordinary discovery opened a new chapter in prion research. Volume I will take you through the fascinating chronicle of prions in mammals, yeast, and fungi.


Contents:

Chapter 1    Transmissible Spongiform Encephalopathy: from the High Middle Ages to Daniel Carlton Gajdusek
Paul Brown

Chapter 2    The Rich Chemistry of the Copper and Zinc Sites in Cellular Prion Protein
Glenn L. Millhauser

Chapter 3    Role of Cellular Prion Protein in the Amyloid-ß Oligomer Pathophysiology of Alzheimer’s Disease
Adam C. Kaufman, Stephen M. Strittmatter

Chapter 4    Cellular Prion Protein and Cancers
Wei Xin, Man-sun Sy, Chaoyang Li

Chapter 5    Insoluble Cellular Prion Protein
Wen-Quan Zou

Chapter 6    Protein Misfolding Cyclic Amplification
Fabio Moda, Sandra Pritzkow, Claudio Soto

Chapter 7    Cofactor Involvement in Prion Propagation
Surachai Supattapone, Michael B. Miller

Chapter 8    Prion Protein Conversion and Lipids
Jiyan Ma

Chapter 9    New Perspectives on Prion Conversion: Introducing a Mechanism of Deformed Templating
Ilia V. Baskakov

Chapter 10   Infectious and Pathogenic Forms of Prion Protein
Emiliano Biasini, David A. Harris

Chapter 11   Cellular Mechanisms of Propagation and Clearance
Hermann M. Schatzl

Chapter 12    Molecular Mechanisms Encoding Quantitative and Qualitative Traits of Prion Strains
Jiri G. Safar

Chapter 13    Modeling the Cell Biology of Prions
Richard Rubenstein, Robert B. Petersen

Chapter 14    Prion Strain Interference   
Charles R. Schutt, Ronald A. Shikiya, Jason C. Bartz
 
Chapter 15   Introduction to Yeast and Fungal Prions
Reed B. Wickner

Chapter 16   Yeast Prions are Pathogenic, in-register Parallel Amyloids
Reed B. Wickner, Herman K. Edskes, David A. Bateman, Amy C. Kelly, Anton Gorkovskiy


PRODUCT DETAILS

ISBN-13: 9781461453048
Publisher: Springer (Springer New York)
Publication date: November, 2012
Pages: 270
Weight: 543g
Availability: POD
Subcategories: Biochemistry, Neurology, Neuroscience, Physiology
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