Main description:

Volume I highlights the association of the cellular prion protein (PrPC) with copper and zinc, the potential roles of PrPC in Alzheimer's disease and cancers, insoluble PrPC, PMCA, molecular and cellular mechanisms of PrPSc formation and clearance, possible co-factors involved in the conversion of PrPC into PrPSc, infectious and pathogenic forms of PrP, cell biology of prions, prion strains and their interference, as well as yeast prions and their inheritable and structural traits. This unique volume will take you through the fascinating chronicle of prions in mammals, yeast, and fungi.

Contents:

Chapter 1 Transmissible Spongiform Encephalopathy: from the High Middle Ages to Daniel Carlton Gajdusek
Paul Brown

Chapter 2 The Rich Chemistry of the Copper and Zinc Sites in Cellular Prion Protein
Glenn L. Millhauser

Chapter 3 Role of Cellular Prion Protein in the Amyloid-ss Oligomer Pathophysiology of Alzheimer's Disease
Adam C. Kaufman, Stephen M. Strittmatter

Chapter 4 Cellular Prion Protein and Cancers
Wei Xin, Man-sun Sy, Chaoyang Li

Chapter 5 Insoluble Cellular Prion Protein
Wen-Quan Zou

Chapter 6 Protein Misfolding Cyclic Amplification
Fabio Moda, Sandra Pritzkow, Claudio Soto

Chapter 7 Cofactor Involvement in Prion Propagation
Surachai Supattapone, Michael B. Miller

Chapter 8 Prion Protein Conversion and Lipids
Jiyan Ma

Chapter 9 New Perspectives on Prion Conversion: Introducing a Mechanism of Deformed Templating
Ilia V. Baskakov

Chapter 10 Infectious and Pathogenic Forms of Prion Protein
Emiliano Biasini, David A. Harris

Chapter 11 Cellular Mechanisms of Propagation and Clearance
Hermann M. Schatzl

Chapter 12 Molecular Mechanisms Encoding Quantitative and Qualitative Traits of Prion Strains
Jiri G. Safar

Chapter 13 Modeling the Cell Biology of Prions
Richard Rubenstein, Robert B. Petersen

Chapter 14 Prion Strain Interference
Charles R. Schutt, Ronald A. Shikiya, Jason C. Bartz

Chapter 15 Introduction to Yeast and Fungal Prions
Reed B. Wickner

Chapter 16 Yeast Prions are Pathogenic, in-register Parallel Amyloids
Reed B. Wickner, Herman K. Edskes, David A. Bateman, Amy C. Kelly, Anton Gorkovskiy