Main description:

Covering ocular pharmacokinetics, pharmacodynamics, and toxicology, Ocular Pharmacology and Toxicology provides ophthalmologists, toxicologists, and pharmacologists with both an introduction to the proper methods for ocular pharmacology and toxicology as well as providing practical methodologies for conducting ocular studies. Expert authors have contributed detailed chapters on study design, analysis, and routes to regulatory approval for various types and routes of ophthalmic drugs. As a volume in the Methods in Pharmacology and Toxicology series, chapters feature the kind of in-depth specifics and implementation advice to ensure successful results.

Practical and authoritative, Ocular Pharmacology and Toxicology serves as an ideal basis of training in the proper design and conduct of essential studies to accurately determine pharmacokinetics and ocular toxicity from the systemic, topical, periocular, or intraocular administration of drugs or compounds, from the use of ocular medical devices and from ocular surgical procedures.

Contents:

1. Challenges in Ocular Pharmacokinetics, Pharmacodynamics, and Toxicology

Brian C. Gilger

2. Selection of Appropriate Animal Models in Ocular Research: Ocular Anatomy and Physiology of Common Animal Models

Brian C. Gilger, Eva Abarca, and Jacklyn H. Salmon

3. Challenges and Strategies in Drug Residue Measurement (Bioanalysis) of Ocular Tissues

Poonam R Velagaleti and Michael H. Buonarati

4. Chemistry, Manufacturing, and Control of Ophthalmic Formulations

Malay Ghosh and Imran Ahmed

5. ADME and Ocular Therapeutics: Retina

Cornelis J. Van der Schyf, Samuel D. Crish, Christine Crish, Denise Inman, and Werner J. Geldenhuys

6. Compositions, Formulation, Pharmacology, Pharmacokinetics, and Toxicity of Topical, Periocular, and Intravitreal Ophthalmic Drugs

Kishore Cholkar, Aswani Dutt Vadlapudi, Hoang M. Trinh, and Ashim K. Mitra

7. Sustained-Release Ocular Drug Delivery Systems: Bench to Bedside Development

Susan S. Lee, Michael R. Robinson, and Scott M. Whitcup

8. The Ophthalmic Examination as It Pertains to General Ocular Toxicology: Basic and Advanced Techniques and Species-Associated Findings

David A. Wilkie

9. Study Design and Methodologies for Evaluation of Anti-Glaucoma Drugs

Paul E. Miller

10. Study Design and Methodologies for Study of Ocular Medical Devices

Joseph W. Carraway and Elaine M. Daniel

11. Methodologies for Microscopic Characterization of Ocular Toxicity

Leandro B.C. Teixeira and James A. Render

12. Nanoparticles for Drug and Gene Delivery in Treating Diseases of the Eye

Shreya S. Kulkarni and Uday B. Kompella