Main description:

Cardiac Drug Development Guide outlines, in detail, the therapeutics of cardiac medicine currently at the cutting edge of scientific research and development around the world. This volume integrates basic and clinical cardiac pharmacology by c- bining, for the first time, both classical and molecular aspects of therapeutic drug development. The chapters comprise a broad spectrum of therapeutic areas and hence involve a comprehensive discussion of molecular, biochemical, and electrophy- ological concepts based on years of in vitro as well as in vivo pharmacological st- ies. In addition, the latter part of the book includes comprehensive clinical cardiac chapters that describe important topics in molecular medicine. These chapters also discuss current clinical therapeutic trends in medicine and provide an evaluation of the efficacy of novel drugs in these areas. Cardiac Drug Development Guide has many distinctive and outstanding features that set it apart from other cardiac pharmacology books. This book introduces topics in an easily understandable format for researchers in many varying disciplines by integrating and thereby simplifying concepts not usually discussed across a broad range of cardiac disciplines and in a highly technical field. Each chapter not only introduces and describes the physiology, pharmacology, and pathophysiology of the disease, but also overviews the clinical implications of drug development, what stages these areas are currently in, and also reviews some of the methodologies involved in drug discovery and development. As a result, this book provides a comprehensive overview of the most advanced procedures in cardiac pharmacology today.

Contents:

I. Introduction

Cardiac Drug Development: From Animal Models to Clinical Trials
Michael K. Pugsley

II . Novel Molecular Targets for Cardiac Drug Development

The Role of Cardiac Pacemaker Currents in Antiarrhythmic Drug Discovery
David A. Saint

Oxygen Free Radicals in Heart Disease: Novel Therapies
Elizabeth Roth and Laszlo Hejjel

Mitogen-Activated Protein Kinases-Mediated Signaling in Cardiac Pathology: A Perspective of Novel Therapeutic Targets?
Tanya Ravingerova, Miroslav Barancik, and Monika Strniskova

Development of Anti-Inflammatory Drugs for Cardiovascular Disease
Melanie B. Smith and David J. Lefer

Development and Use of Platelet Glycoprotein Antagonists in Heart Disease
Joel S. Bennett

The Sodium-Hydrogen Exchange System in the Heart: A Target for the Protection of the Ischemic and Reperfused Heart and Inhibition of Heart Failure
Morris Karmazyn

Nitric Oxide and Cardiac Ischemia
Mariarosaria Bucci, Inmaculada Posadas Mayo, and Giuseppe Cirino

III. Functional Endpoints Evaluating Cardiac Drug Activity

Ionic Mechanisms of Atrial Fibrillation
J. Christian Hesketh and David Fedida

Targeting Ischemic Ventricular Arrhythmias
Michael J. A. Walker and Leon J. Guppy

Biochemical Mediators of Ventricular Arrhythmias in Ischemic Heart Disease
Hugh Clements-Jewery and Michael J. Curtis

Heterologous Expression Systems and Screening Technologies in Ion Channel Drug Discovery
Maurizio Taglialatela

Molecular Diversity of Ion Channels in the Mouse Heart: A Suitable Model for Cardiac Drug Development?
Jeanne M. Nerbonne

Delayed Protection of the Myocardium: A Novel Therapeutic Window for Cardiac Drug Development
Laszlo Szekeres and James Parratt

IV. Clinical Aspects in Cardiac Drug Development

Cardiac TroponinTesting for Detection of Myocardial Infarction: Clinical Utility and Analytical Issues
Fred S. Apple

A Genetic Basis for Cardiac Arrhythmias: Current Status and the Future
Jeffrey A. Towbin, Matteo Vatta, Hua Li, and Neil E. Bowles

Myocardial Adenoviral Vector Delivery for Cardiovascular Gene Therapy
Hendrik T. Tevaearai, Andrea D. Eckhart, and Walter J. Koch

The Role of Pharmacometrics in Cardiovascular Drug Development
Paul J. Williams, Amit Desai, and Ene Ette

Gender Differences in Heart Failure: Concerns for Drug Development
Mark A. Sussman

Angiogenesis Therapies for Coronary Artery Disease: Trials and Tribulations
Michael Simons

Index