Main description:

The book deals with basic cellular and molecular mechanisms associated with aging. It comprehensively describes the important genetic, epigenetic, biochemical and metabolic regulations during aging, as well as some important age-related diseases.The book is divided into four major sections for easy understanding. It takes the readers through the various aspects of aging in a story-like manner. Certain interventions for healthy aging such as dietary restriction, regular exercise and maintaining a balanced and peaceful life-style are also suggested by the experts. The book would be a companion for both beginners, as well as established researchers in the field. It would be useful for science education, research, clinical approach and policy making.

Contents:

I. Alterations in Cellular Mechanisms during Aging
1. Protein Structure and Function in Aging and Age-Related Diseases
2. DNA, DNA Replication and Aging

3. Transcription and Aging
4. Ribosomes, Translation and Aging
5. p53 and Aging
6. Paired box (Pax) Transcription Factors and Aging
7. Telomeres, Telomerase and Aging
8. The Epigenome of Ageing
9. Attaining Epigenetic Rejuvenation: Challenges Ahead
10. Mitochondria as a Key Player in Aging
11. Aging, Free Radicals and Reactive Oxygen Species: an Evolving Concept
12. Stem cells and Aging
13. Can autophagy stop the clock: Unravelling the mystery in Dictyostelium discoideum
14. Aging: Reading, Reasoning and Resolving using Drosophila as a Model System
15. Nothobranchius furzeri as a new model system for aging studies
II. Alterations in Metabolism during Aging and Diseases
16. Aging in muscle
17. Metabolic Diseases and Aging
18. Interplay between Nutrient Sensing Molecules during Aging and Longevity