Main description:

This book describes both the technologies used in the discovery of melanoma biomarkers and the clinical application of these biomarkers for diagnosis and staging of disease, determination of prognosis, treatment planning, monitoring of response to therapy, identification of novel therapeutic targets and drug development. A broad range of biomarkers (DNA/chromosomal, mRNA, microRNA, mitochondrial DNA, epigenetic and protein) is outlined. As therapies for melanoma become increasingly more target specific, the identification, validation and use of biomarkers will invariably play a greater role in the management of patients with this disease. Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma is an essential resource for oncologists, dermatologists, dermatopathologists, general pathologists with an interest in melanoma, and melanoma researchers.

Contents:

Table of Contents:

1. Introduction to Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma
Michael J. Murphy

2. Diagnostic and Prognostic Biomarkers in Melanoma: Current State of Play
Jochen Utikal, Jurgen C. Becker, and Selma Ugurel

3. Molecular Pathogenesis of Melanoma: Established and Novel Pathways
Paolo Antonio Ascierto, Maria Libera Ascierto, Mariaelena Capone, Zendee Elaba, Michael J. Murphy, and Giuseppe Palmieri

4. Staging of Melanoma
Zendee Elaba, Michael J. Murphy, Philip Kerr, and Jane M. Grant-Kels

5. Clinical and Histopathological Parameters in Melanoma
Cheryl Bilinski, Avery LaChance, and Michael J. Murphy

6. Genetic/Epigenetic Biomarkers: Distinction of Melanoma from Other Melanocytic Neoplasms
Minoru Takata

7. mRNA Biomarkers in Melanoma
Giovanna Chiorino and Maria Scatolini

8. Epigenetic Biomarkers in Melanoma
Suhu Liu, Suping Ren, Paul M. Howell Jr., and Adam I. Riker

9. microRNA Biomarkers in Melanoma
Jim Kozubek, Faseeha Altaf and Soheil S. Dadras

10. MicroRNAs as Biomarkers and Therapeutic Targets in Melanoma
Daniel W. Mueller, Anja K. Bosserhoff

11. Mitochondrial DNA Biomarkers in Melanoma
Mark L. Steinberg

12. Tissue-Based Protein Biomarkers in Melanoma: Immunohistochemistry: (A) Diagnosis
Steven J. Ohsie, Basil A. Horst, Alister Cochran, and Scott W. Binder

13. Tissue-Based Protein Biomarkers in Melanoma: Immunohistochemistry: (B) Prognostication
Basil A. Horst, Steven J. Ohsie, Alister Cochran, and Scott W. Binder

14. Tissue-Based Protein Biomarkers in Melanoma: Mass Spectrometry-Based Strategies
Michael J. Murphy, Karim Rezaul, and David K. Han

15. Serological Biomarkers in Melanoma
Mel Ziman, Michael Millward, Robert Pearce, and Mark Lee

16. Molecular Markers of Lymph Node Disease in Melanoma
Sandro Pasquali, Augustinus P.T. van der Ploeg, and Simone Mocellin

17. Melanoma Cell Propagation: Cancer Stem Cell, Clonal Evolution and Interconversion Models of Tumorigenicity
Qiuzhen Liu, Marianna Sabatino, David F. Stroncek, Ping Jin, Francesco M. Marincola, and Ena Wang

18. Surgical Management of Melanoma: Concept of Field Cancerization and Molecular Evaluation of Tissue Margins
Amanda Phelps and Michael J. Murphy

19. Chemotherapy for Melanoma
Hedwig Stanisz, Thomas Vogt, and Knuth Rass

20. Molecular-Targeted Therapy for Melanoma
Alessia E. Russo, Ylenia Bevelacqua, Andrea Marconi, Andrea Veronesi, and Massimo Libra

21. Anti-Angiogenesis Therapy for Melanoma
Roberta Ferraldeschi and Paul Lorigan

22. Immunological Biomarkers and Immunotherapy for Melanoma
Jochen T. Schaefer

23. Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma: An Overview
Ahmad A. Tarhini and John M. Kirkwood