Main description:

In this volume Dr Hui has brought together a comprehensive overview of gestational trophoblastic disease that includes all the currently recognized entities: complete and partial hydatidiform moles, placental site trophoblastic tumor, epithelioid trophoblastic tumor, gestational choriocarcinoma, persistent gestational trophoblastic neoplasia, placental site nodule and exaggerated placental site reaction. Each entity is reviewed in detail, with emphasis on genetic background, clinical presentation, pathologic findings and ancillary studies, differential diagnosis and clinicopathological correlations.

Descriptions of the pathology are supported by numerous excellent photomicrographs. Recent advances in our understanding of the genetics of gestational trophoblastic diseases are stressed. Introductory chapters cover the developmental biology of the placenta and the genetic basis of gestational trophoblastic disease, and one chapter is devoted to the molecular diagnosis of gestational trophoblastic disease. This chapter includes a review of the use of short tandem repeat (STR) genotyping which is of particular value in the diagnosis of hydatidiform moles. The final chapter covers clinical aspects of gestational trophoblastic disease, including treatment. The text throughout is current and thoroughly referenced. This book will be of great value to pathologists, community gynecologists, gynecological pathologists and medical students.

Contents:

Forward

Preface and Dedication

Chapter 1: Gestational Trophoblastic Disease: General Aspects (Pei Hui)

- Historical remarks

- Definition and classification of gestational trophoblastic disease

- Epidemiology and risk factors

- Overview of diagnosis

- Overview of clinical management

- Perspectives

- References

Chapter 2: Developmental Biology of the Placenta (Pei Hui)

- Introduction

- Placenta formation

- Stages of implantation

- Placental trophoblastic cells

- Genomic imprinting and placental development

- Imprinted X chromosomal inactivation and placental development

- Co-evolution of genomic imprinting and imprinted X-chromosome inactivation

- "Parental conflict of interest" theory of genomic imprinting

- References

Chapter 3: Genetic Basis of Gestational Trophoblastic Disease (Pei Hui)

- Introduction

- Androgenetic nature of hydatidiform moles

- Genomic imprinting and hydatidiform moles

- Genetic basis of gestational trophoblastic tumors

- Perspectives

- References

Chapter 4: Complete hydatidiform mole (Pei Hui)

- Introduction

- Pathogenesis

- Clinical presentation

- Pathology

- Ancillary studies

- Differential diagnosis

- Clinicopathological correlations

- References

Chapter 5: Partial hydatidiform mole (Natalia Buza)

- Introduction

- Genetic background

- Clinical presentation

- Pathology gross and microscopic features

- Ancillary studies

- Differential diagnosis

- Clinicopathological correlations

- References

Chapter 6: Placental site trophoblastic tumor (PSTT) (Pei Hui)

- Introduction

- Clinical presentation

- Pathogenesis

- Gross and histological pathology

- Ancillary studies

- Differential diagnosis

- Clinicopathological correlations

- References

Chapter 7: Epithelioid trophoblastic tumor (Katja Gwinn)

- Introduction

- Pathogenesis and molecular genetic aspect

- Clinical presentation

- Pathology

- Ancillary studies

- Differential diagnosis

- Clinicopathological correlations

- References

Chapter 8: Gestational choriocarcinoma (Pei Hui)

- Introduction

- Clinical presentation

- Pathogenesis

- Pathology

- Ancillary studies

- Differential diagnosis

- Clinicopathological correlations

- References

Chapter 9:Persistent gestational trophoblastic neoplasia (Pei Hui)

- Introduction

- Pathology

o Persistent mole

o Invasive mole and metastatic mole

o Gestational trophoblastic tumors

- Prognosis

- References

Chapter 10:Tumor-like trophoblastic conditions (Pei Hui)

- Introduction

- Placental site nodule/plaque (PSN)

o Clinical features

o Pathogenesis

o Pathology

o Ancillary studies

o Differential diagnosis

o Clinicopathological correlations

- Exaggerated placental site reaction (EPS)

o Clinical features

o Pathogenesis

o Pathology

o Ancillary studies

o Differential diagnosis

o Clinicopathological correlations

- References

Chapter 11:Molecular Diagnosis of Gestational Trophoblastic Disease (Pei Hui)

- Introduction

- Genetic basis of molecular testing

- Methods of molecular diagnosis

- STR genotyping diagnosis of hydatidiform moles

- Interpretation of STR PCR data

- Target tissue selection and processing

- Diagnostic pitfalls of STR genotyping

- STR genotyping diagnosis of trophoblastic tumors

- Prospective

- Conclusions

- References

Chapter 12: Clinical aspects of gestational trophoblastic disease (Christine E. Richter and Peter E. Schwartz)

- Introduction

- Diagnosis

- Hydatidiform moles

- Gestational trophoblastic neoplasia

- Treatment of gestational trophoblastic neoplasia

- Treatment of PSTT and ETT

- Treatment failure GTN

- Follow-up GTN

- References

Appendix:

GTD clinicopathological staging forms (AJCC 2010, Seventh Edition, Springer)