Main description:

This volume provides readers a comprehensive and state-of-the-art overview about the range of applications of targeted therapies for solid tumors. The sections of the book have been structured to review the oncogene addicted tumors, the pharmacology and clinical development of new molecularly targeted agents, the use of biomarkers as prognostic, predictive and surrogate endpoints, and the evaluation of tumor response and specific malignancies treated with targeted agents. The book also covers some of the newest developments in cancer therapy that are not adequately covered by any current available literature.

Written by recognized experts in the field, Targeted Therapies for Solid Tumors: A Handbook for Moving Toward New Frontiers in Cancer Treatment provides a unique and valuable resource in the field of molecular oncology, both for those currently in training, and for those already in clinical or research practice.

Contents:

Chapter 1: Introduction
Antonio Russo, Christian Rolfo, and Rafael Rosell

Chapter 2: Oncogene Addiction in Solid Tumors
Stefano Caruso, Daniele Fanale

Chapter 3: Pharmacology and Clinical Development of New Molecularly Targeted Agents
Elisa Giovannetti, Elena Galvani

Chapter 4: Biomarkers as Prognostic, Predictive and Surrogate Endpoints
Francesco Passiglia, Giuseppe Cicero, Marta Castiglia, and Viviana Bazan

Chapter 5: Evaluation of Response in Malignant Tumors Treated with Targeted Agents
Giuseppe Lo Re, Federica Vernuccio, Maria Cristina Galfano, Federico Midiri, and Massimo Midiri

Chapter 6: Targeted Therapies for HER2-Positive Breast Cancer
Maria Vittoria Dieci, Valentina Guarneri, Carlo Alberto Giorgi, and Pierfranco Conte

Chapter 7: Role of PARP Inhibitors in Triple Negative Breast Cancer (TNBC)
Enrico Ricevuto, Katia Cannita, Gemma Bruera, Eleonora Palluzzi, Valentina Cocciolone, Corrado Ficorella, and Antonio Russo

Chapter 8: Targeted Therapies in Squamous Cell Carcinoma of the Head and Neck
Pol Specenier

Chapter 9: Targeted Therapies for NSCLC
Antonio Russo, Christian Rolfo, Francesco Passiglia, and Rafael Rosell

Chapter 10: Targeted Therapies for Gastric Cancer
Nishi Kothari, Khaldoun Almhanna

Chapter 11: Targeted Therapies for Pancreatic Cancer
Leon Mateos L, Grande Pulido E., and Anton Aparicio L.

Chapter 12: Targeted Therapies in Hepatocellular Carcinoma
Fabrizio Bronte, Enrico Bronte, Giuseppe Bronte, and Vito Di Marco

Chapter 13: Targeted Therapies for Colorectal Cancer
Antonio Russo, Antonio Galvano, Giuseppe Bronte, and Marc Peeters

Chapter 14: Targeted Therapy in Gastrointestinal Stromal Tumors
Piotr Rutkowski, Joanna Przybyl, Agnieszka Wozniak, and Giuseppe Badalamenti

Chapter 15: Targeted Therapies in Kidney Cancer
Amparo Sanchez Gastaldo, Aranzazu Gonzalez del Alba, and Ignacio Duran

Chapter 16: Targeted Therapies in Melanoma
Daniele Fanale, Giuseppe Bronte, and Antonio Russo

Chapter 17: Targeted Therapies for Prostate Cancer
Aranzazu Gonzalez del Alba, Luis Leon; Cristina Suarez, and Maria Jose Mendez

Chapter 18: Targeted Therapies for Bone Metastases
Daniele Santini, Chiara Spoto, Vito Longo, Michele Iuliani, Alice Zoccoli, Salvatore Intagliata, Francesco Pantano, and Franco Silvestris