Main description:

Biological rhythms time the ebb and flow of virtually every physiological process, and their mutual coordination guarantees the integrity of the organism over space and time. Aging leads to the disintegration of this coordination, as well as to changes in the amplitude and/or frequency of the underlying rhythms. The results of this are accelerated loss of health during aging, and in experimental model systems curtailed lifespan occurs. This book will examine the machinery that constitutes circadian systems and how they impact physiologic processes. It will also discuss how disturbances of circadian rhythms can lead to complex diseases associated with aging. Much of this treatment will focus on metabolism and genome stability. Importantly, the chapters in this book will encompass work in several different models, in addition to human. The book will conclude with a discussion of modeling approaches to biologic cycles and chronotherapy, for future research and translation.

Contents:

1- The yeast metabolic cycle, cell cycle, and lifespan
Benjamin Tu

2- The Neurospora biological clock and aging
Jonathan Arnold

3- The circadian clock and aging of Drosophila
Jadwiga Giebultowicz

4- Mammalian models of circadian biology with emphasis on aging
Marina Antoch

5- Organization and functional dynamics of circadian clocks in mammalian model systems in relation to aging
Joseph Takahashi

6- Age-related changes in circadian and nuclear receptor cross talk
David Mangelsdorf

7- Circadian integration of whole animal mammalian metabolism and energetics
Joseph Bass

8- Circadian rhythms of metabolism and chromatin remodeling
Paolo Sassone-Corsi

9- The circadian clock and mTOR
Roman Kondratov

10- Cell senescence, DDR, SASP and genomic instability
Judy Campisi

11- Circadian control of DNA repair
Aziz Sancar

12- Epidemiology of circadian disruption and human health
Richard Stevens

13- Impact of melatonin - reciprocal relationship with aging
Russ Reiter

14- Aging and circadian misalignment on inflammation and immune response pathways
Regina Markus

15- Impact of the circadian system and its misalignment on metabolic and cardiovascular dynamics
Frank Scheer

16- Detoxification and the circadian system
Anton Jetten

17- Circadian system and bone metabolism
Paula Witt-Enderby

18- Circadian sleep-wake regulation during aging
Steven Lockley

19- Modeling the eukaryotic cell cycle
John Tyson

20- Circadian system and responses to chronotherapy
William Hrushesky

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