Main description:

The second edition of this text presents an overview of the most recent developments in this area including clinical presentation, etiology, pathogenesis, and differential diagnosis. The rationale for various therapies, including transplantation, is discussed and tissue diagnosis (its pitfalls and strategies for avoiding them) and laboratory support are included. The involvement of all major organ systems including renal/genitourinary, cardiac, gastrointestinal, pulmonary, peripheral nerve/central nervous system, soft tissue, skin, lymph node/spleen and bone marrow pathology is also covered.

Amyloid and Related Disorders, Second Edition will be invaluable to specialized and general pathologists as well as cytopathologists. Other medical professionals may also benefit from this concise update on the systemic amyloidoses.

Contents:

Part I - Introduction/General

Chapter 1: Aspects of the History and Nomenclature of Amyloid and Amyloidosis

Per Westermark

Chapter 2: Amyloid diseases at the molecular level: general overview and focus on AL amyloidosis

Mario Nuvolone, MD, PhD; Giovanni Palladini, MD, PhD; Giampaolo Merlini, MD

Chapter 3: AA Amyloidosis

Amanda K. Ombrello, MD; Ivona Aksentijevich, MD

Chapter 4: Leukocyte cell-derived chemotaxin 2 Amyloidosis (ALECT2)

Oana Madalina Mereuta, MD PhD; Chris P. Larsen, MD; Ahmet Dogan, MD PhD

Chapter 5: The Hereditary Amyloidoses

Merrill D. Benson, MD

Chapter 6: Dialysis-Associated Amyloidosis

Paweena Susantitaphong, MD; Laura M. Dember, MD; Bertrand L. Jaber, MD, MS

Chapter 7: Localized amyloidoses and amyloidoses associated with aging outside the central nervous system

Per Westermark

Chapter 8: Amyloid Deposition in the Central Nervous System

Fausto J. Rodriguez, Maria M. Picken, John M. Lee

Part II - Non-Amyloid Protein Deposits

Chapter 9: Differential Diagnosis of Amyloid in Surgical Pathology: Organized Deposits and Other Materials in the Differential Diagnosis of Amyloidosis

Guillermo A. Herrera and Elba A. Turbat-Herrera

Chapter 10: Light/Heavy Chain Deposition Disease as a Systemic Disorder

Guillermo A. Herrera and Elba A. Turbat-Herrera

Chapter 11: Non-Randall Glomerulonephritis with Non-organized Monoclonal Ig Deposits

Pierre Ronco, Alexandre Karras, and Emmanuelle Plaisier

Chapter 12: Pathologies of renal and systemic intracellular paraprotein storage: crystalopathies and beyond

Maria M. Picken and Ahmet Dogan

Part III - Diagnosis

Chapter 13: Diagnosis of Amyloid Using Congo Red

Alexander J. Howie

Chapter 14: Diagnosis of Minimal Amyloid Deposits by Congo Red Fluorescence and Amyloidtype-specific Immunohistochemistry: A Review

Reinhold P. Linke, MD, PhD

Chapter 15: Thioflavin T Stain: An Easier and More Sensitive Method for Amyloid Detection

Maria M. Picken and Guillermo A. Herrera

Chapter 16: Fat tissue analysis in the management of patients with systemic amyloidosis

Johan Bijzet, Ingrid I. van Gameren, Bouke P.C. Hazenberg

Chapter 17: Generic diagnosis of amyloid - a summary of current recommendations and the editor's comments on Chaps. 13-16

Maria M. Picken

Chapter 18: Typing of Amyloid for Routine Use on Formalin-Fixed Paraffin Sections of 626 Patients by Applying Amyloidtype-Specific Immunohistochemistry: A Review

Reinhold P. Linke, MD, PhD

Chapter 19: Amyloid Typing: Experience from a Large Referral Centre

Janet A. Gilbertson, Julian D. Gillmore and Philip N. Hawkins

Chapter 20: Options for amyloid typing in renal pathology - the advantages of frozen section immunofluorescence and a summary of general recommendations regarding immunohistochemistry methods

Maria M. Picken

Chapter 21: Amyloid typing in plastic embedded tissue by immune-gold-silver method

Anne Raisanen-Sokolowski and Tom Tornroth

Chapter 22: The Role of Immuno-electron Microscopy in Amyloid Typing: The Experience of the Pavia Referral Center

Laura Verga, Patrizia Morbini, Giovanni Palladini, Laura Obici, Gian Luca Capello, Marco Paulli, and Giampaolo Merlini

Chapter 23: Classification of amyloidosis by mass spectrometry-based proteomics

Ahmet Dogan, MD, PhD

Chapter 24: The Role of Differential Proteomics in Amyloid Typing: The Experience of the Pavia Referral Center

Francesca Lavatelli, Francesca Brambilla, Andrea Di Fonzo, Giovanni Ferraro, Giovanni Palladini, Pierluigi Mauri and Giampaolo Merlini

Part IV- Ancillary Studies of Amyloidosis

Chapter 25: Laboratory Support for Diagnosis of Amyloidosis

David L Murray, M.D., Ph.D. and Jerry A. Katzmann, Ph.D.

Chapter 26: Bone Marrow Biopsy and Its Utility in the Diagnosis of AL Amyloidosis

John C. Lee, M.D., Lawreen H. Connors, Ph.D., Carl J. O'Hara, M.D.

Chapter 27: Laboratory Methods for the Diagnosis of Hereditary Amyloidoses

S. Michelle Shiller, Ahmet Dogan, Kimiyo M. Raymond, and W. Edward Highsmith, Jr.

Part V- Organ Involvement in Amyloidoses

Chapter 28: Amyloidoses of the Kidney, the Lower Urinary and Genital Tracts (male and female) and the Breast

Maria M. Picken and Ahmet Dogan

Chapter 29: Cardiac Amyloidosis

Carmela D. Tan, M.D. and E. Rene Rodriguez, M.D.

Chapter 30: Amyloidosis of the Gastrointestinal Tract and Liver

Oscar W. Cummings, M.D., Merrill Benson, M.D.

Chapter 31: Peripheral Nerve Amyloidosis

Adam J. Loavenbruck, JaNean K. Engelstad, Christopher J. Klein

Chapter 32: Amyloidosis of the Lymph Nodes and the Spleen

Filiz Sen MD, Ahmet Dogan MD PhD

Chapter 33: Amyloidosis of the lung

Karen L. Grogg MD, Oana Madalina Mereuta MD PhD, Ahmet Dogan MD PhD

Chapter 34: Cutaneous Amyloidosis

Oana Madalina Mereuta MD PhD, Ahmet Dogan MD PhD

Chapter 35: Iatrogenic pharmaceutical amyloidosis associated with insulin and enfuvirtide administration

Ahmet Dogan MD PhD, Oana Madalina Mereuta MD PhD

Part VI- Clinical Issues and Therapy

Chapter 36: Clinical and pathologic issues in patients with amyloidosis - summary and practical comments regarding diagnosis, therapy and solid organ transplantation

Maria M. Picken and Kevin Barton

Chapter 37: Emerging Therapies for Amyloidosis

Merrill D. Benson

Chapter 38: Modern Therapies in AA Amyloidosis

Amanda K. Ombrello, M.D.

Chapter 39: Medicolegal Issues of Amyloidosis

Timothy Craig Allen, M.D., J.D.

Chapter 40: Amyloidosis from the Patient's Perspective

Muriel Finkel