Main description:

This is the first comprehensive volume on Dipeptidyl Aminopeptidases that can be marketed to a wide variety of disciplines, as well as to a variety of clinicians. Leading experts in the field contribute to this state-of-the-art view on these enzymes. This book comes at a time when our understanding of their function is growing ever more rapidly and therapeutic options have become imminent.

Contents:

Structure and Function.- Peptide Substrates of Dipeptidyl Peptidases.- Phosphorus-Containing Inhibitors of Proteolytic Enzymes.- Biochemical Properties of Recombinant Prolyl Dipeptidases DPP-IV and DPP8.- Prediction of Dipeptidyl Peptidase (DP) 8 Structure by Homology Modelling.- Dpiv-Related Enzymes.- Structure and Function in Dipeptidyl Peptidase IV and Related Proteins.- Expression and Function of Dipeptidyl Peptidase IV and Related Enzymes in Cancer.- DP8 and DP9 have Extra-Enzymatic Roles in Cell Adhesion, Migration and Apoptosis.- In Vivo Effects of a Potent, Selective Dppii Inhibitor.- Expression of Dipeptidyl Peptidase IV-Like Enzymes in Human Peripheral Blood Mononuclear Cells.- Dipeptidyl Peptidase 8 Has Post-Proline Dipeptidyl Aminopeptidase and Prolyl Endopeptidase Activities.- Prolyl Endopeptidase Cleaves the Apoptosis Rescue Peptide Humanin and Exhibits an Unknown Post-Cysteine Cleavage Specificity.- Distribution of Dipeptidyl Peptidase Iv-Like Activity Enzymes in Canine and Porcine Tissue Sections by RT-PCR.- Metabolic Disorders.- Relative Contribution of Incretins to the Glucose Lowering Effect of DP IV Inhibitors in Type 2 Diabetes Mellitus (T2DM).- Dipeptidyl Peptidase IV: A Molecular Switch of Vascular Actions of Neuropeptide Y.- Immune Disorders.- Dipeptidylpeptidase IV (DPIV) and Alanyl-Aminopeptidases (AAPs) as a New Target Complex for Treatment of Autoimmune and Inflammatory Diseases-Proof of Concept in a Mouse Model of Colitis.- Dipeptidyl Peptidases and Inflammatory Bowel Disease.- Possible Role of DP IV Inhibitors in Acne Therapy.- Dipeptidyl Peptidase-IV Activity and/or Structure Homologs (DASH): Contributing Factors in the Pathogenesis of Rheumatic Diseases?.- Neuronal Diseases.- Dipeptidyl Peptidase IV (DP IV, CD26) and Aminopeptidase N (APN, CD13) as Regulators of T Cell Function and Targets of Immunotherapy in CNS Inflammation.- CD26/DP IV in T Cell Activation and Autoimmunity.- Cancer.- DPIV/CD26 and FAP in Cancer: A Tale of Contradictions.- Type-II Transmembrane Prolyl Dipeptidases and Matrix Metalloproteinases in Membrane Vesicles of Active Endothelial Cells.- Extra-Enzymatic Roles of DPIV and FAP in Cell Adhesion and Migration on Collagen and Fibronectin.- Role of Neuropeptide Y and Dipeptidyl Peptidase IV in Regulation of Ewing's Sarcoma Growth.- The Role of CD26/DPP IV in Preservation of Early Pulmonary Graft Function.