Main description:

This book provides acomprehensive overview of cell signalling pathways and morphogens in the genesis of brain tumours. It also explains the role of brain tumour stem cells in the brain tumour progression. It also elucidates the novel early biomarkers that can be utilized to diagnose brain tumours. It presents the basic developmental pathways and morphogens, including retinoic acid and TGF-b that promote brain tumorigenesis. The chapters illustrate the role of stem cells and stem cells mediated cell signalling pathways including, Sonic hedgehog, Notch, Wnt in the brain tumour growth. The chapters also emphasize the role of transcription factors, mainlyNanog, Sox, BMI1, HIF1 and Pax6 in the brain tumouriogensis. It highlights the role of NF-kb, Myc and neurotrophins in the brain tumour development. Finally, the book summarizes the potential early therapeutic targets and targeted drug discovery for brain tumours.

Contents:

Chapter 1: Introduction of Cell signalling Pathways and Brain Tumours

Chapter 2: Wnt cell signalling pathway and brain tumours development

Chapter 3: Notch cell signalling pathway and Brain Tumours

Chapter 4: Shh cell signalling pathway and paediatric brain tumour "Medulloblastoma"

Chapter 5: Role of Shh cell signalling pathway in "glioma"

Chapter 6: Role of stem cell marker NANOG in brain tumours development

Chapter 7: Stem cell factor Sox2 and Brain Tumours Development

Chapter 8: Role of Neurotrophins in brain tumor development

Chapter 9: Role of NFk in brain tumour development

Chapter 10: Role of Myc in brain tumours development

Chapter 11: Role of P53 in Medulloblastoma Development

Chapter 12: Role of Gene TP53 in glioblastoma development

Chapter 13: Role of HIF-1 in Brain Tumour Development

Chapter 14: EGFR and its role in glioma development

Chapter 15: Role of EFGR in medulloblastoma development

Chapter 16: Role of OCT4 in glioblastoma development

Chapter 17: Role of OCT4 in paediatric brain tumour "medulloblastoma" development

Chapter 18: Role of Mitogen activated protein (MAP) Kinase in paediatric brain tumour "medulloblastoma"