Main description:

This book provides a comprehensive, in-depth review of our current understanding of the growth of blood vessels within the eye. Novel therapeutic strategies for the treatment of ocular angiogenesis are discussed, as are the unique challenges presented by delivery of drugs to the eye. The book emphasizes basic principles rather than specific experimental results, although recently acquired data is frequently cited to illustrate points of broader theoretical significance.

Contents:

I. Angiogenesis Study Models
1. Cellular and Molecular Mechanisms of Retinal Angiogenesis by M. A. Behzadian, M. Bartoli, A. B. El-Remessy, M. Al-Shabrawey, D. H. Platt, G. I. Liou, R. W. Caldwell, and R. B. Caldwell

2. Animal Models of Choroidal Neovascularization by M. L. Clark, J. A. Fowler, and J. S. Penn

3. Rodent Models of Oxygen-Induced Retinopathy by S. E. Yanni, G. W. McCollum, and J. S. Penn

4. Animal Models of Diabetic Retinopathy by T. S. Kern

5. Neovascularization in Models of Branch Retinal Vein Occlusion by R. P. Danis and D. P. Bingaman

II. Molecular Characterization
6. Vasculogenesis and Angiogenesis in Formation of the Human Retinal Vasculature by T. Chan-Ling

7. IGF-1 and Retinopathy by L. E. H. Smith

8. Hypoxia and Retinal Neovascularization by B. A. Berkowitz

9. Hypoxia Inducible Factor-1 and VEGF Induction by A. Madan

10. The Role of Protein Kinase C in Diabetic Retinal Vascular Abnormalities by J. K. Sun and G. L. King

11. Eph Receptor Tyrosine Kinases: Modulators of Angiogenesis by J. Chen, D. Brantley-Siders, and J. S. Penn

12. Adenosine in Retinal Vasculogenesis and Angiogenesis in Oxygen-Induced Retinopathy by G. A. Lutty and D. S. McLeod

13. The Regulation of Retinal Angiogenesis by Cyclooxygenase and the Prostanoids by G. W. McCollum and J. S. Penn

14. Extracellular Proteinases in Ocular Angiogenesis by A. Das and P. G. McGuire

15. Oxygen-Independent Angiogenic Stimuli by J. M. Holmes, D. A. Leske, and W. L. Lanier

16. Growth Factor Synergy in Angiogenesis by A. Ljubimov

17. Pigment Epithelium-Derived Factor and Angiogenesis by J. Amaral and S. P. Becerra

18. Circulating Endothelial Progenitor Cells and Adult Vasculogenesis by S. Caballero, N. Sengupta, L. C. Shaw, and M. B. Grant

III. Applications to Clinical Conditions

19. Retinopathy of Prematurity by D. L. Phelps

20. Angiogenesis in Sickle Cell Retinopathy by G. A. Lutty and D. S. McLeod

21. Diabetic Retinopathy by R. N. Frank

22. Systems for Drug Delivery to the Posterior Segment of the Eye by A. L. Weiner and D. A. Marsh

23. Novel Therapeutic Strategies for Posterior Segment Neovascularization by D. P. Bingaman, X. Gu, A. M. Timmers, and A. Davis

24. Choroidal Neovascularization in Age-Related Macular Degeneration--From Mice to Man by L. Berglin