Main description:

The book explores cutting-edge strategies to overcome proteasome inhibitor resistance, including the second generation 20S proteasome inhibitors, novel combinational therapies, and new targets in the ubiquitin-proteasome pathway (e.g., ubiquitin E3 ligases, deubiquitinases, 19S proteasomal ATPases, histone deacetylases, oxidative stress and proteotoxic stress pathways and pharmacogenomic signature profiling) in resistant cancer cells. The mechanisms of action and resistance of proteasome inhibitors, such as bortezomib and carfilzomib in human cancers, including multiple myeloma, mantle cell lymphoma, acute leukemia, and solid tumors are explored in depth in this volume.

This timely volume unveils the most current discoveries of the mechanisms behind proteasome inhibitor resistance, which will help illuminate the future of cancer therapies.

Contents:

Preface - Q Ping Dou

Proteasome inhibitors and lessons learned from their mechanisms of action and resistance in human cancer - Sara M. Schmitt, Rahul R. Deshmukh, Q. Ping Dou

Resistance to proteasome inhibitors in multiple myeloma - Francesca Cottini MD, Anna Guidetti MD, Claudia Paba Prada MD, Teru Hideshima MD PhD, Michelle Maglio, Cindy Varga MD, Dharminder Chauhan JD PhD, Jacob Laubach MD, Kenneth C Anderson MD, Paul G Richardson MD

Overcoming bortezomib resistance: a review on the second generation proteasome inhibitor carfilzomib in the treatment of multiple myeloma - Hans C. Lee, M.D., and Robert Z. Orlowski, Ph.D., M.D.

Proteasome inhibitors in the treatment of multiple myeloma and amyloidosis - Jeffrey A. Zonder, MD

Profiling bortezomib resistance in multiple myeloma: implications in personalized pharmacotherapy - Amit Mitra, Holly Stessman, John Shaughnessy, and Brian Van Ness

Targeting mantle cell lymphoma with a strategy of combined proteasome and histone deacetylase inhibition - Michael Batalo, Prithviraj Bose, Beata Holkova, Steven Grant

Pre-clinical studies on the molecular basis of bortezomib resistance and modalities to overcome resistance in hematological malignancies - Jacqueline Cloos, Denise Niewerth, Gerrit Jansen

Overcoming inherent resistance to proteasome inhibitors in head and neck cancer: Challenges and new approaches - Jason I. Kass, Jennifer R. Grandis and Daniel E. Johnson

Targeting the proteasome pathway for the treatment of solid tumors - Nisar Ahmad, Elias Anaissie and James J. Driscoll