Main description:

This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and the ubiquitin protein family. Following a basic introduction, it explains how defects in protein homeostasis contribute to numerous pathologies, including cancer, neurodegeneration, inflammation and a number of rare diseases. In addition, it discusses, the role of protein homeostasis in cellular development and physiology.

Highlighting the latest research in the field of protein homeostasis and its implications for various clinically relevant diseases, the book appeals to researchers and clinicians, while also offering a reference guide for scholars who are new to the field.

Contents:

PART I Cancer

1. Ubiquitin-regulated cell proliferation and cancer -Beatriz Perez-Benavente, Alihamze Fathinajafabadi Nasresfahani and Rosa Farras

2. Ubiquitin, SUMO and NEDD8 as therapeutic targets in cancer -Pierre Gatel, Marc Piechaczyk and Guillaume Bossis

3.The proteasome system in health and disease - Olivier Coux, Barbara Zieba and Silke Meiners

4. Proteostasis dysregulation in pancreatic cancer- Leena Arpalahti, Caj Haglund, and Carina I. Holmberg

5. Divergent modulation of proteostasis in prostate cancer- Petek Ballar Kirmizibayrak, Burcu Erbaykent Tepedelen, Oguz Gozen, Yalcin Erzurumlu

6. Resistance to the proteasome inhibitors: lessons from multiple myeloma and mantle cell lymphoma - Maria Gonzalez-Santamarta, Gregoire Quinet, Diana Reyes-Garau, Brigitte Sola, Gael Roue and Manuel S. Rodriguez

PART II Neurodegeneration

7. Altered proteostasis in neurodegenerative tauopathies - Katerina Papanikolopoulou and Efthimios MC Skoulakis

8. The ubiquitin system in Alzheimer's Disease - Lee D. Harris, Sarah Jasem & Julien D. F. Licchesi

9. The interplay between proteostasis systems and Parkinson's disease - Diana F. Lazaro and Tiago F. Outeiro

10. Machado-Jospeh Disease: A stress combating deubiquitylating enzyme changing sides - Nico P. Dantuma and Laura K. Herzog

PART III Infection, inflammation and developmental disorders

11. SUMO and cytoplasmic RNA viruses: from enemies to best friends - Ahmed El Motiam, Santiago Vidal, Rocio Seoane, Yanis H Bouzahe, Jose Gonzalez-Santamaria, Carmen Rivas

12. The role of proteostasis in the regulation of cardiac intercellular communication - Daniela Batista-Almeida, Tania Martins-Marques, Teresa Ribeiro-Rodrigues, Henrique Girao

13. By the tips of your cilia: ciliogenesis in the retina and the ubiquitin-proteasome system - Vasileios Toulis, Gemma Marfany

14. TRIM E3 ubiquitin ligases in rare genetic disorders - Germana Meroni

PART IV Diet

15. We are what we eat: Ubiquitin-proteasome System (UPS) modulation through dietary products -Eleni Panagiotidou and Niki Chondrogianni