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Prions and Diseases
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Main description:

Transmissible spongiform encephalopathies (TSE), now broadly known as prion diseases, have been recognized for nearly 300 years in animals and almost 100 years in humans. However, the nature of the transmissible agent had largely remained a mystery until Stanley Prusiner discovered the infectious isoform of the prion protein (PrP), named prion or scrapie PrP (PrPSc), in 1982. The subsequent modern studies with protein chemistry and molecular biology in cell culture, transgenic animals, and cell-free systems, including the revolutionary protein-misfolding cyclic amplification (PMCA), have greatly advanced our understanding of the pathogenesis of prion diseases and facilitated the identification of new prion diseases in animals and humans. In Prions and Prion Diseases, more than 60 leading researchers and clinicians worldwide provide an up-to-date development in many aspects of these unique infectious pathogens and their associated diseases. As a result, the book contains by far the most authoritative views about the past, present, and future of prions and prion diseases.


Feature:

Authored by a team of leading researchers and clinicians

Updated knowledge and concepts on pathogenic prion proteins and prion diseases

Present state-of the art findings and hypotheses beyond prions and prion diseases


PRODUCT DETAILS

ISBN-13: 9781461453437
Publisher: Springer (Springer New York)
Publication date: November, 2012
Pages: 670
Availability: Available
Subcategories: Biochemistry, Neurology, Neuroscience, Physiology

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