Main description:

Pharmacogenomics supports personalized medicine by translating genome-based knowledge into clinical practice, offering enhanced benefit for patients and health-care systems at large. Current routine practice for diagnosing and treating patients is conducted by correlating parameters such as age, gender and weight with risks and expected treatment outcomes. In the new era of personalized medicine the healthcare provider is equipped with improved ability to prevent, diagnose, treat and predict outcomes on the basis of complex information sources, including genetic and genomic data. Targeted therapy and reliable prediction of expected outcomes offer patients access to better healthcare management, by way of identifying the therapies effective for the relevant patient group, avoiding prescription of unnecessary treatment and reducing the likelihood of developing adverse drug reactions.

Contents:

Introduction

Preventive and Predictive Genetics: A perspective
Godfrey Grech, Christian Scerri, Jeanesse Scerri, Tomris Cesuroglu

Roadmap to Drug Development Enabled by Pharmacogenetics
James P Bishop, Sonal B Halburnt, Patrick A Akkari, Scott Sundseth, Iris Grossman

Preventative and Predictive Genetics: Towards Personalised Medicine
Aiden Flynn, Craig Ledgerwood & Caroline O'Hare

Pharmacokinetics and Pharmacogenetics: bringing the magic bullet closer to reality
Janet Mifsud, Marc Maliepaard

Pharmacogenetics of Adverse Drug Reactions
Richard Myles Turner, Munir Pirmohamed

Pharmacogenomics for haemoglobinopathies therapeutics
Aikaterini Gravia, Vasiliki Chondrou, Theodora Katsila, George P. Patrinos

Pharmacogenetics of Neurodegenerative Disorders
Ramon Cacabelos, Clara Torrellas, Pablo Cacabelos, Maria J. Villanueva, Sergio Pineiro, Cristina Solveira

Pharmacogenetics of asthma
Anthony G Fenech, Ian Sayers, Michael A Portelli

Pharmacogenetics and antineoplastic therapies
Jai N. Patel, Christine M. Walko, Federico Innocenti

Pharmacogenetics of coumarin anticoagulant therapy
Rianne M.F. van Schie, Talitha I. Verhoef, Anthonius de Boer, Felix J.M. van der Meer,William K. Redekop, Tom Schalekamp, and Anke-Hilse Maitland-van der Zee

Implementation of Genomic Medicine: tools and challengesGodfrey Grech, Ron van Schaik, Joseph Borg

Ethical Considerations in the Genomic Era
Bridget Ellul

Index