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New Concepts of Antiviral Therapy
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Main description:

Antiviral drugs are vital - but imperfect - tools for treatment and prevention of viral infections. Undesirable effects, from drug resistant viruses to low oral bioavailability, toxicity and severe side effects limit clinical usefulness. These factors drive demand for improved antiviral strategies. This book offers an up-to-date review of new drugs and targets, novel modes of action, vector-based treatments and even the blocking of defined genes by inhibiting mRNA formation (siRNA). Includes contributions by acknowledged experts; the book will serve as a compendium for R&D and educational professionals, and be of value for students.


Contents:

Contents Part 1. Concepts of therapy for RNA viruses
Therapeutic vaccination in chronic hepadnavirus infection by Michael Rogendorf and Mengji Lu
Characterization of targets for antiviral therapy of Flaviridae infections by Peter Borowski
Inhibition of Hepatitis C virus by nucleic acid-based antiviral approaches by Michael Frese and Ralf Bartenschlager
Inhibitors for respiratory viruses by Ernst Kuechler and Joachim Seipelt
Anti-viral approaches against influenza viruses by Stephan Pleschka, Stephan Ludwig, Thorsten Wolff and Oliver Planz
A new approach to an Influenza virus live vaccine: Modification of the cleavage site of the haemagglutine by reverse genetics by Jurgen Stech, Holger Garn and Hans-Dieter Klenk
New concepts in anti-HIV therapies by Justin Stebbing, Mark Bower and Brian Gazzard
Evaluation of current strategies to inhibit HIV entry, integration and maturation by Jaqueline D. Reeves, Stephen D. Barr and Stephan Poehlmann
Managing antiretroviral resistance by Barbara Schmidt, Monika Tschoschner, Hauke Walter and Klaus Korn Part 2. Concepts of therapy for DNA viruses
Selective inhibitors of the replication of poxviruses by Johan Neyts and Erik de Clercq
Maribavir: A promising new antiherpes therapeutic Agent by Karen K. Biron
Benzimidazle-D-ribonucleosides as antiviral agents that target HCMV terminase by John C. Drach, Leroy B. Townsend and Elke Bogner
Recent developments in anti-herpesviral therapy based on protein kinase inhibitors by Thomas Herget and Manfred Marschall
Immune therapy against papillomavirus-related tumors in humans by Lutz Gissmann Part 3. Concepts of therapy for emerging viruses
The SARS Corona virus receptor ACE-2 A potential target for antiviral therapy by Jens H. Kuhn, Sheli R. Radoshitzky, Wenhui Li, Swee Kee Wong, Hyeryun Choe and Michael Farzan
Therapy of Ebola and Marburg virus infections by MikeBray Part 4. General concepts of therapy
Proteasome inhibitors as complementary or alternative antiviral therapeutics by Susanna Proesch and Marion Kaspari
Human monoclonal antibodies for prophylaxis and therapy of viral infections by Jan ter Meulen and Jaap Goudsmit
Vector-based antiviral therapy by Armin Ensser Index


PRODUCT DETAILS

ISBN-13: 9780387310466
Publisher: Springer (Springer-Verlag New York Inc.)
Publication date: June, 2006
Pages: 558
Weight: 2120g
Availability: Available
Subcategories: Biochemistry, Infectious Diseases, Microbiology, Pharmacology
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