Main description:

Molecular Biomarkers in Cancer Detection and Monitoring of Therapeutics: Volume Two: Diagnostic and Therapeutic Applications discusses how molecular biomarkers are used to determine predisposition, facilitate detection, improve treatment and offer prevention guidelines for different cancers. It focuses on novel diagnostic techniques based on molecular biomarkers and their impact on treatment, covering different cancer types such as tumors in the nervous system, head and neck, oral and GI tractor, lung, breast, gastric system, leukemia and urogenital tract cancers. For each type, the book discusses the best diagnostic techniques and therapeutic approaches, thus helping readers easily identify the best solution for each case.

This is a valuable resource for cancer researchers, oncologists, graduate students and other members of the biomedical field who are interested in the potential of biomarkers in cancer research.

Contents:

UNIT 1: Tumor invading nervous system
1. Introduction
2. Epidemiology
3. Signs and symptoms
4. Specific Advancements
5. Treatment Types

UNIT 2: Head and neck cancer
6. Advances in Screening
7. Early detection and treatment strategies

UNIT 3: Oral and GI tract cancers (including Colon)
8. Incidence
9. Etiology and genetic predisposition
10. Nutritional impact
11. Role of gut microbes
12. Diagnostic markers
13. Treatment protocols and response

UNIT 4: Lung cancer
14. Predisposition markers including etiological factors
15. Diagnostic molecular markers
16. Genetic basis of population variations
17. Treatment protocols and response

UNIT 5: Cancer affecting upper aero duct
18. Introduction
19. p53 and other pathway and targets
20. Risk factors associated
21. Prognostics
22. Conclusion

UNIT 6: Leukemias
23. Introduction
24. Role of Bcr-Abl and other variants
25. Philadelphia translocation: molecular basis and implications
26. Epidemiology
27. Prognostic markers

UNIT 7: Breast and uterine cancer
28. Introduction
29. Etiological markers
30. Role of estrogen
31. Phytoestrogen
32. Conclusion

UNIT 8: Gastric Cancer
33. Introduction
34. Epidemiology
35. Predisposition markers
36. Signs and symptoms
37. Prognostic protocols
38. Prevention
39. Treatment

UNIT 9: Hepatocellular carcinoma
40. Introduction
41. Molecular epidemiology
42. Signs and symptoms
43. Diagnostic markers
44. Prevention
45. Treatment

UNIT 10: Human Papilloma Virus in Cervical and other cancers
46. Introduction
47. Molecular aspects of HPV including screening technologies
48. Etiological aspects
49. Signs and symptoms of cancers associated with HPV
50. Prevention
51. Treatments available including vaccines

UNIT 11: Urogenital Tract Cancers
52. Bladder
53. Kidney
54. Prostate
55. Testicular
56. Ovarian
57. Molecular markers in their predisposition diagnosis, etiological factors, and treatment protocols and treatment responses

UNIT 12: Rare cancers catching up with common cancers: A case of biliary tract cancer genetics with special emphasis on Gallbladder carcinoma

UNIT 13: Molecular Pathogenesis of Gallbladder Cancer: Translational Implications

UNIT 14: Assessing role of GWAS identified various mutations, e.g. 5p15.33 and 8q24.21 genetic variants in gallbladder cancer
58. Predisposition
59. Treatment response and
60. Toxicity in North-Indian population