Main description:

Hµ?? ??? ´ ?´???? ??´??????? o?o????o ´ ?? o ?? ´ ????o? ???o???? ´ ?? ? ???????´???? ?o? ????o? ´ ?o? ??? ?? ?o? ?????? ´ ?? µ? ???? o? ´ ??? µ?? ??o ?? ???? ´ ?o. Great art is found wherever man achieves an understanding of self and is able to express himself fully in the simplest manner. Odysseas Elytis (1911-1996) 1979 Nobel Laureate in Literature The magic of Papadiamantis Biopharmaceutics, pharmacokinetics, and pharmacodynamics are the most important parts of pharmaceutical sciences because they bridge the gap between the basic sciences and the clinical application of drugs. The modeling approaches in all three disciplines attempt to: • describe the functional relationships among the variables of the system under study and • provide adequate information for the underlying mechanisms. Due to the complexity of the biopharmaceutic, pharmacokinetic, and ph- macodynamic phenomena, novel physically physiologically based modeling - proaches are sought.

Feature:

Brings together the disciplines of Biopharmaceutics, Pharmacokinetics and Pharmacodynamics (BPP)

Coveres the theory with specific examples behind all three under the perspective of heterogeneous processes while also treating the current state of the art in applied and theoretical BPP

Can serve as a text for graduate courses in bioengineering or BPP and as working tool for the empirical scientist who wants to expand into theory or the mathematician working in the biopharmaceutical field

Back cover:

The state of the art in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics Modeling is presented in this book. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. The book is divided into four parts; the first deals with the fundamental principles of fractals, diffusion and nonlinear dynamics; the second with drug dissolution, release, and absorption; the third with empirical, compartmental, and stochastic pharmacokinetic models, and the fourth mainly with nonclassical aspects of pharmacodynamics. The classical models that have relevance and application to these sciences are also considered throughout. Many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods.

This timely and useful book will appeal to graduate students and researchers in pharmacology, pharmaceutical sciences, bioengineering, and physiology.

Contents:

Basic Concepts.- The Geometry of Nature.- Diffusion and Kinetics.- Nonlinear Dynamics.- Modeling in Biopharmaceutics.- Drug Release.- Drug Dissolution.- Oral Drug Absorption.- Modeling in Pharmacokinetics.- Empirical Models.- Deterministic Compartmental Models.- Stochastic Compartmental Models.- Modeling in Pharmacodynamics.- Classical Pharmacodynamics.- Nonclassical Pharmacodynamics.