Main description:

This volume contains the proceedings of the fifth Colloque Medecine et Re- cherche organized by the Fondation Ipsen pour la Recherche Therapeutique and devoted to Alzheimer's disease. It was held in Lille on October 16, 1989 and dedicated to imaging, cerebral topography and Alzheimer's disease. The proceedings of the previous meetings were published as the present one in the same series: Immunology and Alzheimer's disease (A. Pouplard-Barthelaix, J. Emile, Y. Christen eds.), Genetics in Alzheimer's disease (P.-M. Sinet, Y. Lamour, Y. Christen eds.) in 1988, Neuronal graJting and Alzheimer's disease (F. Gage, A. Privat, Y. Christen eds.), Biological markers oJ Alzheimer's disease (F. Boller, R. Katzman, A. Rascol, J.-L. Signoret, Y. Christen eds.) in 1989. The next meeting of the series entitled growth Jactors and Alzheimer 's disease was being held in Strasbourg on April 25, 1990. The proceedings will be published by the end of this year. Yves Christen Vice-President of the Fondation Ipsen pour la Recherche Therapeutique Acknowledgements: The editors wish to express their gratitude to Y. Lamour (Paris), A. Syrota (Paris), J. Clarisse (Lille), F. Boller (Paris), C.
Manelfe (Tou- louse) and M. Steinling (Lille) for their collaboration as chairmen for the meeting, Mary Lynn Gage for her editorial assistance and Jacqueline Mervaillie for the organization of the meeting. Contents Topography of Alzheimer's Disease: Involvement of Assoeiation Neoeortiees and Conneeted Regions; Pathologieal, Metabolie and Cognitive Corre1ations; Relation to Evolution S. I. Rapoport ...1 .

Contents:

Topography of Alzheimer's Disease: Involvement of Association Neocortices and Connected Regions; Pathological, Metabolic and Cognitive Correlations; Relation to Evolution.- Cellular Pathology in Alzheimer's Disease: Implications for Corticocortical Disconnection and Differential Vulnerability.- Distribution of Neurochemical Deficits in Alzheimer's Disease.- Topography of Lesions in Alzheimer's Disease: A Challenge to Morphologists.- Computer Tomography and Study of the Anatomical Changes in Alzheimer's Disease.- Could "Leuko-araiosis" Be Secondary to Wallerian Degeneration in Alzheimer's Disease?.- Topographical Comparison of Lesions in Trisomy 21 and Alzheimer's Disease: A Study with PET, Anatomical and Neuropathological Investigations.- Cognitive Deficits and Local Metabolic Changes in Dementia of the Alzheimer's Type.- Patterns of Cerebral Metabolism in Degenerative Dementia.- Cortical Functional Impairment in Dementia of the Alzheimer Type: Studies with Positron Emission Tomography.- Brain Imaging with SPECT in Alzheimer's Disease.- Hemodynamic Subtypes of Dementia of the Alzheimer Type: Clinical and Neuropsychological Characteristics.- Nuclear Magnetic Resonance Study of Phospholipid Metabolites in Alzheimer's Disease.- Summary Comments on Presentations.