Main description:

Neurodegenerative disorders are common and devastating. Rationally, the most effective treatments will target pathogenetic mechanisms. While alternative - proaches, based on alleviating the symptoms of patients with Alzheimer disease, Parkinson disease, Huntington disease, prion disorders or amyotrophic lateral sc- rosis, can be expected to reduce suffering, studies of pathogenesis of these a- related disorders will be most important for enabling early diagnosis and the creation of preventative and curative treatments. It is in this context that a recent IPSEN rd meeting (The 23 Colloque Medecine ' et Recherche, April 28, 2008) focused on a role for disruption of intracellular traf?cking in neurodegenerative disorders. The meeting captured emerging insights into pathogenesis from disrupted traf?cking and processing of proteins implicated in age-related degeneration. Protein folding, traf?cking and signaling were the principal topics covered at the meeting. Importantly, the presenters pointed to the importantly intersection of these themes. While the proteolytic processing of APP into its toxic product, the A? peptide, is an intensive focus of work in many laboratories, it is only relatively recently that investigators have begun to examine in depth the cellular compartments and traf?
cking events that mediate APP processing and how derangement of tr- ?cking pathways could impact them.

Contents:

Amyloid Precursor Protein Sorting and Processing: Transmitters, Hormones, and Protein Phosphorylation Mechanisms.- Intramembrane Proteolysis by ?-Secretase and Signal Peptide Peptidases.- Axonal Transport and Neurodegenerative Disease.- Simple Cellular Solutions to Complex Problems.- Tau and Intracellular Transport in Neurons.- Signaling Between Synapse and Nucleus During Synaptic Plasticity.- Axonal Transport of Neurotrophic Signals: An Achilles' Heel for Neurodegeneration?.- Membrane Trafficking and Targeting in Alzheimer's Disease.- Huntington's Disease: Function and Dysfunction of Huntingtin in Axonal Transport.- The Role of Retromer in Neurodegenerative Disease.- Regulation of Endocytic Trafficking of Receptors and Transporters by Ubiquitination: Possible Role in Neurodegenerative Disease.- The Sortilin-Related Receptor SORL1 is Functionally and Genetically Associated with Alzheimer's Disease.- Regulation of Transport and Processing of Amyloid Precursor Protein by the Sorting Receptor SORLA.