Main description:

Seventeen cutting-edge chapters review both basic research and clinical applications of chromosomal markers of cancer. The new markers offer great promise, not only for their clinical utility in diagnosis, prognosis, and disease monitoring, but also for their contributions to a better understanding of the mechanisms of tumor development and progression. The chapters-all written by leading authorities-skillfully reveal fresh insights into the translational role of cytogenetics in identifying the cellular and molecular changes that occur in cancer. Coverage is devoted to many tissue systems-colon, breast, prostate, lung, skin, brain, and kidney-where the diagnostic and prognostic utility of chromosome markers is clearly demonstrated. A seminal book certain to become the front-line reference and authoritative resource needed by all scientists and clinicians engaged in cancer research, diagnosis, and management.

Contents:

Part I. Perspectives: Relation of Other Genetic Measures to Cytogenetics. An Introduction to Cancer Markers and Cytogenetics, Sandra R. Wolman, Stewart Sell, and Eric Wolman. Assessment of Genetic Changes in Human Cancers Using Flow and Image Cytometry, T. Vincent Shankey and Cees J. Cornelisse. In Situ Hybridization and Comparative Genomic Hybridization, Anton H. N. Hopman, Christina E. M. Voorter, Ernst J. M. Speel, and Frans C. S. Ramaekers. Nucleic Acid Amplification Methods for Identifying Cytogenetic Abnormalities, Timothy J. O'Leary. Part II. Organ and Site-Specific Tumors. Direct Demonstration of Lineage Specificity in Hematologic Neoplasms, Sakari Knuutila. Breast Tumor Cytogenetic Markers, Marilyn L. Slovak. Karyotypic Characteristics of Colorectal Cancer, Georgia Bardi, Nikos Pandis, Felix Mitelman, and Sverre Heim. Renal and Bladder Cancers, Jonathan A. Fletcher. Cytogenetic Markers in Selected Gynecological Malignancies, Urvashi Surti and Lori Hoffner. Prostate Cancer, Arthur R. Brothman and Briana J. Williams. Chromosomes in Lung Cancer, Daphne W. Bell and Joseph R. Testa. Cytogenetic Biomarkers in Skin Cancer, Maria J. Worsham, S. David Nathanson, Min Lee, and Sandra R. Wolman. Brain Tumors, Joan Rankin Shapiro and Adrienne C. Scheck. Cytogenetic Abnormalities Associated with Endocrine Neoplasia, Stefan K. G. Grebe, Norman L. Eberhardt, and Robert B. Jenkins. Pancreatic Exocrine Tumors, Constance A. Griffin. Soft Tissue Sarcomas, Julia A. Bridge. Special Techniques in Cytogenetics, Linda A. Cannizzaro. Index.