Main description:

An unprecedented compilation of state-of-the-art advances in clinical research by premier clinical scientists around the world. This volume discusses the methods of clinical research and the interpretation of their results in studies of normal individuals, obese subjects, and patients with diabetes mellitus. Along the way, the authoritative contributors writing here illuminate how changes in the hormone action and substrate metabolism of healthy humans may lead to obesity and noninsulin-dependent diabetes mellitus.

Contents:

Part I: Obesity. Energy Metabolism and Obesity, James O. Hill. Metabolic Parameters and Energy Expenditure Before and After Weight Loss, John M. Amatruda. Regulation of Food Intake and Body Weight, Michael W. Schwartz, Denis G. Baskin, Karl J. Kaiyala, Steven C. Woods, and Daniel Porte, Jr. Mechanisms of Insulin Resistance in Obesity, David E. Kelley and Jean-Aime Simoneau. Effects of Obesity on Lipid Metabolism, Ahmed H. Kissebah and Glenn R. Krakower. Part II: Noninsulin-Dependent Diabetes Mellitus. Genetics of Noninsulin-Dependent Diabetes Mellitus (NIDDM), Henning Beck-Nielsen, Allan Vaag, and Kirsten Ohm Kyvik. Insulin Secretion in Type II Diabetes Mellitus, Yogish C. Kudva and Peter C. Butler. Insulin Action and Insulin Resistance in Noninsulin-Dependent Diabetes Mellitus, John J. Nolan and Jerrold M. Olefsky. Dyslipidemia in Noninsulin-Dependent Diabetes Mellitus, Lisa A. Kosmiski and Robert H. Eckel. Exercise and Noninsulin-Dependent Diabetes Mellitus (NIDDM), Judith G. Regensteiner, Suzanne L. Brandenberg, and Jane E. B. Reusch. Glucose Toxicity and Insulin Resistance in NIDDM, Hannele Yki-Jarvinen. Energy Metabolism and Sympathetic Activity in Patients with Insulin Resistance, Luc Tappy and Nicolas Paquot. Effects of NIDDM on Vascular Tone Regulation, Alain D. Baron and Helmut O. Steinberg. Part III: Insights Gained from Other Insulin-Resistance Syndromes. Insulin Resistance in the Polycystic Ovary Syndrome, Andrea Dunaif and Carol Beth Book. Dietary Management of NIDDM, Frank Q. Nuttall and Mary C. Gannon. Hypertension and Insulin Resistance, Andrea Natali, Stefano Taddei, and Ele Ferrannini. Lessons Learned from Clinical and Basic Research Applied to the Study of Patients with Severe Insulin Resistance, David E. Moller and Heike Benecke. Treatment of Obesity Through Changes in Lifestyle, Rena R. Wing. Syndrome X: Past, Present, and Future, Gerald M. Reaven. Index.