Main description:

A unique, integrated collection of original contributions on the molecular biology, physiology, and pathology of endothelin. Leading academic, clinical, and industrial researchers summarize the dramatic recent progress in endothelin research and indicate the optimal direction of future studies. The contributors produce a critical evaluation of endothelin chemistry and pharmacology, its mechanism of action, and its physiological functions. The book is certain to become the new standard reference source for both basic scientists and informed clinicians who want a clear idea of the roles endothelin may play in cardiovascular physiology and pathology.

Contents:

Endothelin Receptor Subtypes and Tissue Distribution, D. M. Pollock. Molecular Biology of the Endothelin Receptors, J. A. Lee, E. H. Ohlstein, C. E. Peishoff, and J. D. Elliott. Molecular Biology of Endothelin-Converting Enzyme (ECE), R. Takayanagi, K. Ohnaka, W. Liu, T. Ito, and H. Nawata. Endothelin Receptor-Signaling Mechanisms in Vascular Smooth Muscle, E. R. Decker and T. A. Brock. Mechanisms of Endothelin-Induced Mitogenesis in Vascular Smooth Muscle, T. Force. The Renal and Systemic Hemodynamic Actions of Endothelin, R. O. Banks, D. M. Pollock, and J. Novak. The Development of Specific Endothelin-Receptor Antagonists, T. D. Warner. Pathophysiological Role of Endothelin and Potential Therapeutic Targets for Receptor Antagonists, D. P. Brooks, D. K. Jorkasky, M. I. Freed, and E. H. Ohlstein. Index.