Main description:

This edited volume studies gut microbiota peculiarities in elderly, in senescence-related and environmental-related alterations of gut microbiota in chronic diseases.
Aging, as a physiological process mediated through several regulatory pathways and transcription factors, is generally speaking associated to a relentless functional decline and increasing risk of chronic diseases. Growing data on gut microbiota quali-quantitative changes in aging gut, and the opportunity to study by advanced NGS and metabolomic technologies, now offers novel horizons to link such changes to disease risks and to theoretically the weapons for gut microbiota intervention as an effective therapeutic tool.

Chapters are divided into clear sections, starting with the aging perspective, then moving from chronic diseases to neurodegenerative diseases and cancer. The final parts focusses on interventions. Contributors are well-reputed and dedicated scientists in clinics and experimental medicine from 4 different continents who have provided their contribution keeping the polar star on aging as a guide while investigating their gut microbiota in occurrence and progression of disease together with proposed preventing, monitoring and therapeutic interventions.

In the wide offer of books on gut microbiota, this age-thematic volume will be a valuable source of updated information for a wide group of readership including gerontologists, geriatricians, medical specialists of several fields, PhDs, basic scientists and public/private research entities focused on potential intervention in and through gut ecosystem.

This book will stimulate a large number of basic scientists and clinicians to review their once organ (or cellular line)-specific knowledge and widen either their pathophysiological mechanisms understanding while providing novel ways to prevent, monitor and treat diseases from eyes to bones.

Contents:

Section -1: The gut microbiota in ageing

Chapter 1 Limin ZHANG, Chinese Academy of Sciences (CAS) Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Innovation Academy of Precision Measurement Science and Technology, CAS, Wuhan 430071, China; zhanglm@wipm.ac.cn The Gut Microbiota and Its Metabolites Contribute to Ageing and Ageing-related Diseases

Chapter 2 Simone RAMPELLI Unit of Microbial Ecology of Health, Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy. simone.rampelli@unibo.it Ageing and human gut microbiome: the taxonomic and functional transition towards an elderly-type microbiome

Chapter 3 Niharika A DUGGAL Institute of Inflammation and Ageing (IIA) Office 6 , Birmingham University Research Labs. Queen Elizabeth Hospi^ Ageing of the gut microbiome and its potential contribution towards immunesenescence and inflammaging

Chapter Birbal SINGH; ICAR-Indian Veterinary Research Institute, Regional Station, Palampur. India. bsbpalampur@yahoo.co.in Gut Microbiome and Virome: Anti-aging interventions

Chapter 5 Consolato Maria SERGI, Anatomic Pathology Division, Children's Hospital of Eastern Ontario (CHEO), University of Ottawa, 401 Smyth Road Ottawa, ON K1H 8L1 Canada

Tel: 613-737-7600 x 2427 | Fax: 613-738-4837 biotechlab@gmail.com, csergi@cheo.on. https://orcid.org/0000-0002-2779-7879 Bile microbiota profile in ageing and age-related disease

Chapter 6 Brandi MILLER, USF Center for Microbiome Research, University of South Florida, Tampa, Florida, USA bcmiller1@usf.edu ; Hariom YADAV, USF Center for Microbiome Research, University of South Florida, Tampa, Florida, USA, hariom.yadav@gmail.com Gut Microbiota and eating disorders on extremes of aging

Section -2: Chronic diseases and gut microbiota

Chapter 7 Dario PITOCCO, Diabetes Care Unit, Catholic University, Universitario Agostino Gemelli, L.Go Agostino Gemelli, 800168, Policlinico Rome, Italy. dario.pitocco@unicatt.it DIABETES MELLITUS AND MICROBIOTA: KNOWLEDGE AND PERSPECTIVES

Chapter 8 Arunkamar RADHAKRISHAN, Pharmacology at Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Tamilnadu, India. Orchid. 0000-0002-7657-7530 arunrmbbs1978@gmail.com 0000-0002-7657-7530 Aging Gut Microbiota and Chronic Kidney Disease

Chapter 9 Almagul KUSHUGULOVA, Dimitri Poddighe, Jeannette Kunz Department of Medicine, Nazarbayev University School of Medicine and Center for Life Sciences, NLA, Nazarbayev University, National Laboratory, Nur-Sultan, Kazakhstan, akushugulova@nu.edu.kz; Gut Microbiota in Elderly Onset Rheumatoid Arthritis

Chapter 10 Satya PRAKASH, Faculty of Medicine, McGill University, Montreal, Canada. Satya Prakash, Prof. ; Combating the sustained inflammation involved in aging and neurodegenerative diseases with probiotics

Chapter 11 JAGJIT YADAV Pulmonary Pathogenesis and lmmunotoxicology Laboratory,

Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine,Cincinnati, Ohio 45267, USA. pulmolab137@gmail.com, yadavjs@ucmail.uc.edu Lung and Gut Microbiota Interactions with Air Pollution and Aging in Human Chronic Diseases

Chapter 12 Surajit PATHAK, Department of Medical Biotechnology, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education (CARE), Chettinad Hospital and Research Institute (CHRI), Kelambakkam, Chennai 603 103, India. surajit.pathak@gmail.com AGING GUT MICROBIOTA AND SARCOPENIA SIGNALING

Section -3: Gut Microbiota in Neurodegernative diseases and Cancer

Chapter 13 Masaaki HIRAYAMA, Kinji OHNO. Department of Pathophysiological Laboratory Sciences, Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan. hirasan@met.nagoya-u.ac.jp, ohnok@med.nagoya-u.ac.jp; Gut microbiota changes and Parkinson's Disease: what do we know, which avenues ahead.

Chapter 14 Ting SHEN, Hsin-Yi LAI Department of Neurology of the Second Affiliated Hospital, Interdisciplinary Institute of Neuroscience and Technology, Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China. shenting@zju.edu.cn, laihy@zju.edu.cn Gut microbiota, Alzheimer and psychiatric diseases: unveiling the relationships and treatment options

Chapter 15 ROBERTO CATANZARO, Dept of Clinical and Experimental Medicine, Section of Gastroenterology, University of Catania, Catania, Italy. rcatanza@unict.it; Aging gut microbiota and colorectal cancer pathways correlations

Section -4: Interventions on gut microbiota

Chapter 16 Ying-Chieh TSAI, Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 11221, Taiwan tsaiyc66@gmail.com Gerobiotics: Probiotics for healthy aging

Chapter 17 Fang HE Department of Nutrition, Food Safety and Toxicology, West China School of Public Health, Sichuan University, China. nrb47389@nifty.com, hf18602880124@163.com Screening potential probiotics against obesity and metabolism abnormalities in the elderly

Chapter 18 Loo Keat WEI, Department of Biological Science, Faculty of Science, Universiti Tunku Abdul Rahman, Kampar, Perak, Malaysia lookw@utar.edu.my Microbiome and probiotics for ischemic stroke

Chapter 19 Cong HUANG, Department of Sports Science, Zhejiang University cohuang@zju.edu.cn Physical exercise, gut microbiota, in aging process: from osteoporosis to preventive bone health strategy

Chapter 20 E.M SHANKAR, Indrail CHATTOPADHYAY, Division of Infection Biology and Medical Microbiology, Department of Life Sciences, Central University of Tamil Nadu (CUTN), Thiruvarur 610005, India. shankarem@cutn.ac.in; 0000-0002-7866-9818 indranil@cutn.ac.in; Gut microbiota peculiarities in aged HIV-infected individuals: Molecular understanding and therapeutic perspectives