Main description:

Communication between cells via intercellular channels - gap junctions - appears essential to certain developmental processes and appropriate organ function. Gap Junctions in Development and Disease aims to describe the molecular events underlying impaired development and disease. Beginning with a comprehensive review of various mouse and human genes encoding the channel-forming connexins, later chapters describe several connexin mutations associated with human diseases such as hereditary deafness and female infertility. Erroneous signaling mediated by the interaction of mutant connexins with other proteins, thought to be responsible for dysfunction of organs such as heart, muscle, brain, skin, lens, placenta, and endocrine tissue in both mice and men, is also addressed.

Although the question of why some mutations in gap-junction proteins lead to specific phenotypes remains to be answered, the reviews in this book provide an intriguing insight into the future direction of this research field.

Contents:

1 Connexin and Pannexin Genes in the Mouse and Human Genome
Klaus Willecke, Jurgen Eiberger and Julia von Maltzahn 2 Essential Role of Gap Junctions during Development and Regeneration of Skeletal Muscle
Julia von Maltzahn and Klaus Willecke 3 Connexins in Cardiac Development: Expression, Role, and Transcriptional Control
Daniel B. Gros, S. Alcolea, L. Dupays, S. Meysen, L. Miquerol, M. Theveniau-Ruissy, BEJ Teunissen, MFA Bierhuizen 4 Gap Junction and Connexin Remodelling in Human Heart Disease
Nicholas J. Severs, Emmanuel Dupont, Riyaz Kaba and Neil Thomas 5 Gap Junction Expression in Brain Tissues with Focus on Development
Rolf Dermietzel and Carola Meier 6 Connexins Responsible for Hereditary Deafness - The Tale Unfolds
Martine Cohen-Salmon, Francisco J. del Castillo, and Christine Petit 7 Human Connexins in Skin Development and Skin Disorders
Gabriele Richard 8 Intercellular Communication in Lens Development and Disease
Adam M. DeRosa, Francisco J. Martinez-Wittinghan, Richard T. Mathias, Thomas W. White 9 Connexin Modulators of Endocrine Function
Philippe Klee, Nathalie Boucard, Dorothee Caille, Jose Cancela, Anne Charollais, Eric Charpantier, Laetitia Michon, Celine Populaire, Manon Peyrou, Rachel Nlend Nlend, Laurence Zulianello, Jacques-Antoine Haefliger, and Paolo Meda 10 Roles of Gap Junctions in Ovarian Folliculogenesis: Implications for Female Infertility
Gerald M. Kidder 11 Placental Connexins of Mice and Men
Caroline Dunk, Mark Kibschull, Alexandra Gellhaus, Elke Winterhager and Stephen Lye 12 Connexins in Growth Control and Cancer
Christian C. Naus, Gary S. Goldberg and Wun Chey Sin