In recent decades eicosanoids have been attracting an increasing amount of attention as a result of their important physiological roles in many areas of biology and medicine. The eicosanoids comprise the prostaglandins, thromboxanes and leukotrienes and are products of arachidonic acid, an essential polyunsaturated fatty acid stored in tissue phospholipids. Disturbances of eicosanoids and their metabolic products play a regulatory role in many types of cell injuries and diseases. One of the most exciting areas of eicosanoid research pinpoints their participation in the control of cell proliferation and differentiation. Eicosanoids form a link between different fields of research into such areas as cancer, inflammation and radiation-induced injury. This link provided the impetus for the development of the conference series of which the present volume represents the proceedings of the Second International Conference, held in Berlin in October 1991.
Preface. Enzymes of Eicosanoid Biosynthesis. Lipid Peroxidation. Eicosanoid Receptors. Signal Transduction. Inflammation. Radiation-Induced Injury and Radioprotection. Multistage Carcinogenesis. Oncogenes and Growth Factors. Cytokines. Lipid Mediators of Growth and Differentiation. Invasion and Metastasis. Growth Control by PAF and Related Alkyl Ethers. Clinical Implications. Index.