Main description:

This volume contains the proceedings of the First International Conference on Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury held in Detroit, Michigan on October 11-14, 1989. The program consisted of 83 oral and 29 poster presentations, 74 of which are included in these proceedings. The major sponsors of the conference were the Armed Forces Radiobiology Research Institute, located in Bethesda, Maryland, the Radiation Oncology Research and Development Center of the Gershenson Radiation Oncology Center, Harper Hospital in Detroit, Michigan, and Schering AG of West Germany. Eighteen other organizations provided additional support. The conference was unique in its attempt to link the eicosanoid and lipid researchers in the radiobiology and cancer disciplines. The diverse roles that eicosanoids and other bioactive lipids play in these biological phenomena including the participation of lipid oxidation in conversion of procarcinogens, positive and negative modulation of tumor growth, immunomodulation, tissue injury, and yet protection and enhancement of cancer therapy, necessitated scientific interaction to sort out and understand these complex and sometimes contradictory observations. The success of this effort is reflected not only through these proceedings, but also through the decision to continue the conference series with a second meeting to be held in Berlin between September 17-21, 1991.

Contents:

Phospholipid turnover oxygenases and fatty acid metabolism.- 1 Immunobiochemical and Molecular Biological Studies on Arachidonatev12-Lipoxygenase of Porcine Leukocytes.- 2 Transcellular Biosynthesis of Leukotrienes: Is Leukotriene A4 a Mediator?.- 3 The Occurence of Thromboxane Synthase in Tumor Cells.- 4 Stimulation and Inhibition of Oxygen Radical Formation by Ascorbic Acid and 13-Cis-Retinoic Acid.- 5 Fatty Acid Cyclooxygenase Metabolism of Arachidonic Acid in Human Tumor Cells.- 6 Identification of Linoleic Acid Metabolism as a Component of the Epidermal Growth Factor Signal Transduction Pathway in BALB/c 3T3 Fibroblasts.- 7 Localization and Expression of the Eicosanoid Metabolizing P4501VA Gene Family in Rat Tissues and Hepatic Tumors.- 8 Deficient Lipoxin Formation in Chronic Myelogenous Leukemia.- Radiation and Chemical Carcinogenesis.- 9 Radiation Injury and Carcinogenesis.- 10 Tumor Promotion and the Arachidonate Cascade.- 11 Eicosanoids and Bioactive Lipids as Modifiers of Multistage Carcinogenesis In Vitro.- 12 Prevention of Peroxide Produced DNA Strand Scission in Human Tumor Cells by Lipoxygenase Inhibitors.- 13 8-Hydroxydeoxyguanosine, a DNA Adduct Formed by Oxygen Radicals: Its Implications on the Mutagenic and Carcinogenic Action of Oxygen Radical-Forming Agents.- 14 Reaction of DNA Peroxyl Radicals with Cysteamine and Glutathione: The Formation of Sulfoxyl Radicals.- 15 Fatty Acid-Induced Modulation of Carcinogenesis in Human and Mouse Mammary Explant Cultures.- 16 Radiation Protection and Cancer Therapy by Linoleate.- Lipid Peroxidation, Eicosanoid biosynthesis, and Radiation induced tissue injury.- 17 An Overview of Eicosanoid-lnduced Radiation Protection.- 18 Vascular Myointimal Proliferation.- 19 Absence of Prostaglandin E2-lnduced Radioprotection in Two Cell Lines Lacking Specific PGE2-Binding Sites.- 20 Radiation-Induced Decrease in Rat Abdominal Aortic Reactivity to U46619: Amelioration with Indomethacin and WR2721.- 21 Antioxidants and Prevention of the Hepatocellular Damage Induced by Glutathione-Depleting Agents.- 22 The Effects of Oxygen Radical-Mediated Pulmonary Endothelial Damage on Cancer Metastasis.- 23 Radiation Enhanced Tumor Cell Receptor Expression and Metastasis.- 24 Leukotriene Production by Gamma Irradiated Macrophage Cells.- 25 Lipid Peroxidation in Late Radiation Injury of the Rat Spinal Cord.- 26 The Transfer RNAs of the Irradiated Mouse Spleen Contain Queuine.- 27 Behavioral Toxicity of Radioprotective Bioactive Lipids.- 28 Prostaglandins, Radiation, and Thermoregulation.- Antioxidant Enzyme Action.- 29 Phenols and Polyphenols as Antioxidants and Anticancer Agents.- 30 Initiation of the Cyclooxygenase Reaction Via Peroxidase Enzyme Intermediates.- 31 Kinetic Basis for the Impaired Oxygenation of Eicosapentaenoate by Prostaglandin Endoperoxide Synthase.- 32 Biochemistry of Oxidant Injury.- 33 Effects of Dietary Fish Oil and Corn Oil on Protein Kinase C Distribution in the Colon.- Dietary lipid actions.- 34 Dietary Fat and Mammary Gland Developmental Growth in the Immature Female Mouse.- 35 Modulation of Mammary Carcinogenesis by Eicosanoid Synthesis Inhibitors in Rats Fed High Levels of Linoleate.- 36 Enhancement of Colonic Carcinogenesis by Dietary Fat: Role of Essential, Oxidized, Polyunsaturated and Saturated Fatty Acids.- 37 Eicosanoid Synthesis in Mammary Tumors of Rats Fed Varying Types and Levels of N-3 and/or N-6 Fatty Acids.- Immunomodulation.- 38 Lipoxin Formation During Neutrophil-Platelet Interactions: A Role for Leukotriene A4 and Platelet 12-Lipoxygenase.- 39 Involvement of Arachidonic Acid Metabolites in the Transcriptional Regulation of CSF-1 Gene Expression by Tumor Necrosis Factor.- 40 Modulation of Spleen and Thymus Lymphoid Subsets by In Vivo Administration of DI-M-PGE2 in Normal and Tumor-Bearing Mice.- Receptor Modulation of lipid Metabolism.- 41 G Protein Involvement in Signal Transduction.- 42 Regulation of Protein Kinase C.- 43 Modulated Intercellular Communication: Consequence of Extracellular Molecules Triggering Intracellular Communication.- 44 Growth Factor Regulation of Prostaglandin H Synthase Gene Expression.- 45 Enhanced Eicosanoid Release In Ras-Transformed Cells.- 46 Stimulation of de novo Synthesis of Prostaglandin H Synthetase (PHS) in Rat Tracheal Epithelial Cells by TPA Involves Activation of Protein Kinase C.- 47 Mitogenic Effects of Eicosanoids in Human Airway Epithelial Cells.- Eicosanoid Modulation of receptor Expression.- 48 Lipoxygenases, Integrin Receptors, and Metastasis.- 49 The Lipoxygenase Metabolite of Arachidonic Acid, 12-(S)-HETE, Induces Cytoskeleton Dependent Upregulation of Integrin ?IIb?3 in Melanoma Cells.- 50 Eicosanoid Metabolism and Tumor Cell Endothelial Cell Adhesion.- Tumor Growth invasion and differentiation.- 51 Levels of Phosphoserine, Phosphothreonine and Prostaglandins in a Rat Transplantable Hepatoma and Prostatic Tumor.- 52 Role of Arachidonic and Linoleic Acid Metabolites in Growth Regulation of Syrian Hamster Embryo Fibroblasts: Studies with Tumor Suppressor Gene (+) and Suppressor Gene (-) Phenotypes.- 53 Intercellular Communication Among SV40-Transformed Rat Granulosa Cells May be an Index of Differentiation.- 54 Effects of the Immunostimulator Corynebacterium Parvum on Mouse NC Tumour Growth, Spread and Prostanoid Formation.- 55 Effects of 12-Hydroxyeicosatetraenoic Acid on Release of Cathepsin B and Cysteine Proteinase Inhibitors from Malignant Melanoma Cells.- 56 Role of Arachidonic Acid in Collagenase IV Production and Malignant Behavior of Tumor Cells.- Effects of Eicosanoid analogs on tumor growth and Metastasis.- 57 Eicosanoids and Radioprotection of Cultured Cells.- 58 Increased Mouse Survival by 16, 16-Dimethyl Prostaglandin E2 Pretreatment and/or Bone Marrow Transplantation After Supra-Lethal Whole Body Irradiation.- 59 Novel 5-Lipoxygenase Inhibitor (SC-41661) Reduces Human Ovarian Cancer Cell Invasion and Ascitic Tumor Growth.- 60 NSAID Indomethacin Enhanced Cytostatic Effect of Cis-Platinum of the Proliferation of Prostaglandin Producing and Non-producing Cancers in Cell Line.- 61 Control of Tumor Cell Induced Endothelial Cell Retraction by Lipoxygenase Metabolites, Prostacyclin, and Prostacyclin Analogues.- 62 Antimetastatic Action in Mice of PGI2 Analog Iloprost.- 63 Antimetastatic Activity of a Stable Prostacyclin Analogue: Effect on Platelet Aggregation and Host Immunocompetence in the Mouse.- Paf & Ether lipids - Role in radiation injury and tumor growth.- 64 Role of Platelet-Activating Factor in Immune Process.- 65 Cyclopentenone Prostaglandins: Anti-Proliferative and Anti-Viral Actions and Their Molecular Mechanism.- 66 Membrane-Targeted Biochemical Effects and the Role of Cellular Differentiation in the Selective Antitumor Actions of Alkylmethoxy-glycerophosphocholine.- 67 Anticancer Activity and Effect on Protein Kinase C (PKC) of Synthetic Phospholipid Analogs.- 68 Relationship Between Transformed Phenotype and Ether-Linked Lipids.- 69 Mechanism of the Cytotoxic Interaction Between ET-18-OMe and Heat.- Clinical Implications.- 70 Inhibition of Prostaglandin Production in Malignant Tumors: Implications to Radiotherapy.- 71 Enhanced Formation of Leukotriene C4 in Chronic Myelogenous Leukemia Leukocytes.- 72 Clinical Anticancer Effects of Oral and Intratumoral Prostaglandin Inhibitors.- 73 Prognostic Importance of Thromboxane in Breast Cancer.- 74 Chronic Nonsteroidal Antiinflammatory Drug Use in a Cohort of Patients with Advanced Lung and Colon Cancer.