COX-2 inhibitors are important drugs with analgesic and anti-inflammatory effects. The discovery of COX-2, the evolution of drug development in this field and the implications of these developments in patient therapy are topics of this volume. This book presents both pre-clinical and clinical information and is important for clinicians interested in the latest information about this class of drugs, for researchers and for students in the field.
GIVES BACKGROUND INFORMATION ABOUT THE DISCOVERY OF COX-2 PROVIDES AN EXCELLENT OVERVIEW OF THE PHARMACOLOGY AND TOXICOLOGY OF COX-2 AGENTS PROVIDES INFORMATION ABOUT EFFECTS OF COX-2 ON THE CARDIOVASCULAR SYSTEM, LUNGS, KIDNEY, ULCERS AND REPRODUCTION TARGETS MAJOR BIOLOGICAL SYSTEMS WHERE COX-2 INHIBITORS HAVE THE POTENTIAL TO BE DIFFERENT FROM NON-SELECTIVE INHIBITORS AND REVIEWS EVIDENCE FOR AND AGAINST THIS
List of contributors. Preface. R. M. Botting and J. H. Botting: The discovery of COX-2. Lawrence J. Marnett and Amit S. Kalgutkar: Structural diversity of selective COX-2 inhibitors. Guenter Trummlitz, Joanne van Ryn and Timothy D. Warner: The molecular and biological basis for COX-2 selectivity. Kim Rainsford: Pharmacology/ toxicology of COX-2 agents. Frank Degner: Efficacy and gastrointestinal safety of selective COX-2 inhibitors. Joanne van Ryn and Michel Pairet: Role of COX-2 in ulcers and ulcer healing. Rahul Nayak and Brendan F. McAdam: COX-2 and the cardiovascular system. Dirk O. Stichtenoth: Effects on the kidney: Role of COX-2 inhibitors. Koichi Hashimoto and R. Stokes Peebles Jr.: Effects on the lungs: Role of COX-2 inhibitors. Phillip R. Bennett and Aarthi R. Mohan: Reproduction: Role of COX-2 and its inhibition. Kirsi Saukkonen, Christianne J. Buskens, Anna Sivula, Bastiaan P. van Rees, Tiina-Liisa Erkinheimo, Johanna Rintahaka, Leena Pohjola, J. Jan B. van Lanschot, G. Johan A. Offerhaus, Caj Haglund and Ari Ristimäki: COX-2 in cancer. Index