Main description:

This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy.

Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail.

This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia.

Contents:

Chapter 1Title: Epidemiology including genetic predispositionAuthors: Professor Richard Houlston (richard.houlston@icr.ac.uk), Institute of Cancer Research, Royal Marsden, London and Professor Martin Stanulla (stanulla.martin@mh-hannover.de), Hannover University.Chapter 2Title: Clinical FeaturesAuthor: Dr Nicholas Goulden (Nicholas.goulden@gosh.nhs.uk), Great Ormond Street Hospital, LondonChapter 3Title: Diagnostic flow cytometry and immunophenotypic classificationAuthor: Dr Dario Campana (paedc@nus.edu.sg), National University of Singapore.Chapter 4Title: CytogeneticsAuthors: Professor Anthony Moorman (anthony.moorman@newcastle.ac.uk) and Professor Christine Harrison (christine.harrison@newcastle.ac.uk) both at Leukaemia Cytogenetics Reference Laboratory, Newcastle University.Chapter 5Title: Molecular geneticsAuthors: Dr Charles Mullighan, St Jude's Hospital, Memphis, USAChapter 6Title: Pharmacology including pharmacokinetics, pharmacodynamics and pharmacogeneticsAuthor: Professor Mary Relling (mary.relling@stjude.org) St Jude's Hospital, Memphis, USAChapter 7Title: Minimal Residual DiseaseAuthor: Jacques Van Dongen (vandongen@immu.fgg.eur.nl), Rotterdam University, NLChapter 8Title: Treatment - first lineAuthor: Ajay Vora (ajay.vora@sch.nhs.uk) , Sheffield Children's NHS Trust, UKChapter 9Title: Treatment - relapseAuthor: Vaskar Saha (v.saha@manchester.ac.uk) , Manchester University, UKChapter 10Title: Treatment - new drugsAuthor: Michel Zwaan (c.m.zwaan@erasmusmc.nl), Rotterdam, NLChapter 11Title: Treatment - immune based approachesAuthors: Antibodies - Arend Von Stackelberg (Arend.Stackelberg@charite.de) , Charite Hospital, BerlinCellular therapy - Persis Amrolia (persis.amrolia@gosh.nhs.uk), Great Ormond Street Hospital, London, UKChapter 12Title: Supportive careAuthor: Deepa Bhojwani (deepa.bhojwani@chla.org), UCLA, CA, USAChapter 13Title: Developing world perspectiveAuthor: Allen Yeoh